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Stock award plan (Details 3) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 8,054	$ 4,621	$ 26,130	$ 12,605
Unrecognized compensation cost	75,200		$ 75,200
Weighted average remaining service period for recognition of unrecognized compensation cost			2 years 10 months 24 days
Research and development
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	3,828	2,363	$ 12,452	6,517
General and administrative
Share-based compensation expense recorded in the statement of operations
Share-based compensation expense	$ 4,226	$ 2,258	$ 13,678	$ 6,088

X

- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



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