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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Revenues:        
Net product revenue $ 9,772 $ 81 $ 21,002 $ 81
Collaboration revenue 2 716 547 11,280
Grant revenue 2 897 2,483 1,226
Total revenues 9,776 1,694 24,032 12,587
Operating expenses:        
Research and development 30,640 18,765 86,768 52,967
Selling, general and administrative 21,368 10,530 56,193 26,803
Total operating expenses 52,008 29,295 142,961 79,770
Loss from operations (42,232) (27,601) (118,929) (67,183)
Interest (expense)/income, net (852) 354 170 774
Other expense, net (51) (35) (507) (75)
Loss before income tax expense (43,135) (27,282) (119,266) (66,484)
Income tax expense (88)   (233)  
Net loss $ (43,223) $ (27,282) $ (119,499) $ (66,484)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 33,908,853 29,351,693 33,528,833 28,441,827
Net loss per share - basic and diluted (in dollars per share) $ (1.27) $ (0.93) $ (3.56) $ (2.34)