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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Cash flows from operating activities    
Net loss $ (119,499) $ (66,484)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 2,079 1,693
Change in valuation of warrant liability (152) 78
Non-cash interest expense 736  
Amortization of debt issuance costs 37  
Amortization of premiums on investments 1,319 1,225
Share-based compensation expense 26,130 12,605
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (748) (1,232)
Receivables (3,582) (338)
Deposits and other assets 183 (937)
Accounts payable and accrued expenses 2,871 4,286
Other long-term liabilities (69) (68)
Deferred revenue (3,310) (109)
Net cash used in operating activities (94,005) (49,281)
Cash flows from investing activities    
Purchases of fixed assets (1,764) (1,156)
Purchases of marketable securities (134,299) (132,602)
Sale & redemptions of marketable securities 167,082 101,775
Net cash provided by/(used in) investing activities 31,019 (31,983)
Cash flows from financing activities    
Payments on long-term debt   (49)
Proceeds from exercise of options 8,689 389
Net proceeds from public offerings   118,383
Debt issuance costs related to convertible notes (4,650)  
Proceeds from issuance of convertible notes 150,000  
Net cash provided by financing activities 154,039 118,723
Effect of exchange rate changes on cash (89)  
Net increase in cash and cash equivalents 90,964 37,459
Cash and cash equivalents, beginning of period 49,748 15,414
Cash and cash equivalents, end of period 140,712 52,873
Supplemental disclosure of cash information    
Cash paid for interest   1
Supplemental disclosures of non-cash information related to investing and financing activities    
Change in unrealized loss on marketable securities $ (582) $ (139)