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v3.3.1.900

Commitments and contingencies (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Commitments and contingencies |  |  |
Operating Leases, Rent Expense, Net | $ 1,800 | $ 900 | $ 700
Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity |  |  |
2016 | 1,529 |  |
2017 | 966 |  |
2018 | 1,035 |  |
2019 | 176 |  |
Total future minimum lease payments | 3,706 |  |
Funding agreement | Wellcome trust | Expected in second quarter 2016 |  |  |
Other contingencies |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay | 800 |  |
Funding agreement | Wellcome trust | Maximum |  |  |
Other contingencies |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay | $ 68,900 |  |

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- Definition Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=6584154&loc=d3e38371-112697 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6453985&loc=d3e41502-112717 + Details
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- Definition Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=6584154&loc=d3e38371-112697 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6453985&loc=d3e41502-112717 + Details
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