XML 53 R38.htm IDEA: XBRL DOCUMENT
v3.3.1.900

Selected quarterly financial data (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2015
Selected quarterly financial data (Unaudited) |
Summary of quarterly data |
|  | For the quarters ending |
|  | March 31 |  | June 30 |  | September 30 |  | December 31 |
2015: |  |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 5,069 |  | $ | 6,161 |  | $ | 9,772 |  | $ | 12,694 |
Collaboration and grant revenue |  |  | 2,413 |  |  | 613 |  |  | 4 |  |  | 40 |
Operating expenses |  |  | 45,553 |  |  | 45,400 |  |  | 52,008 |  |  | 60,935 |
Loss from operations |  |  | (38,071 | ) |  | (38,626 | ) |  | (42,232 | ) |  | (48,201 | )
Net loss |  |  | (37,915 | ) |  | (38,361 | ) |  | (43,223 | ) |  | (50,948 | )
Basic and diluted net loss per common share(1) |  | $ | (1.15 | ) | $ | (1.14 | ) | $ | (1.27 | ) | $ | (1.50 | )
2014: |  |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | — |  | $ | — |  | $ | 81 |  | $ | 636 |
Collaboration and grant revenue |  |  | 9,217 |  |  | 1,677 |  |  | 1,613 |  |  | 12,022 |
Operating expenses |  |  | 23,429 |  |  | 27,046 |  |  | 29,295 |  |  | 44,888 |
Loss from operations |  |  | (14,212 | ) |  | (25,369 | ) |  | (27,601 | ) |  | (32,230 | )
Net loss |  |  | (14,098 | ) |  | (25,104 | ) |  | (27,282 | ) |  | (27,269 | )
Basic and diluted net loss per common share(1) |  | $ | (0.58 | ) | $ | (0.86 | ) | $ | (0.93 | ) | $ | (0.84 | )
(1) | The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.

X
- References No definition available. + Details
Name: | us-gaap_QuarterlyFinancialInformationDisclosureAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the quarterly financial data in the annual financial statements. The disclosure includes financial information for each fiscal quarter for the current and previous year, including revenues, gross profit, income (loss) before extraordinary items and cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a)-(j) -URI http://asc.fasb.org/extlink&oid=35737889&loc=d3e1280-108306 + Details
Name: | us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration