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v3.3.1.900

The Company (Detail) $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Aug. 04, 2014 | Aug. 31, 2014 state item | Dec. 31, 2015 USD ($) country | Aug. 31, 2015 | Dec. 31, 2014 USD ($)
Minimum age of ambulatory patient | 5 years | 5 years |  |  |
Number of States In European Economic Area | state |  | 31 |  |  |
Period of placebo controlled clinical trail |  | 336 days |  |  |
Number of patients tested in placebo controlled clinical trail | item |  | 174 |  |  |
Number of countries made availability of Translama on a commercial basis | country |  |  | 17 |  |
Accumulated deficit. | $ |  |  | $ (592,998) |  | $ (422,551)
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |
Interest rate |  |  |  | 3.00% |

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