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Stock award plan (Tables) | 12 Months Ended
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Dec. 31, 2015
Stock award plan |
Summary of stock option activity |
|  | Number of options |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value |
|  |  |  |  |  |  |  | (in thousands) |
Outstanding at December 31, 2012 |  |  | 42,394 |  | $ | 474.00 |  |  |  |  |  |  |
Granted |  |  | 2,117,113 |  | $ | 11.29 |  |  |  |  |  |  |
Exercised |  |  | — |  | $ | — |  |  |  |  |  |  |
Forfeited |  |  | (63,915 | ) | $ | 12.57 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2013 |  |  | 2,095,592 |  | $ | 20.24 |  |  |  |  |  |  |
Granted |  |  | 1,639,996 |  | $ | 31.09 |  |  |  |  |  |  |
Exercised |  |  | (108,645 | ) | $ | 11.00 |  |  |  |  |  |  |
Forfeited |  |  | (193,971 | ) | $ | 32.91 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2014 |  |  | 3,432,972 |  | $ | 25.00 |  |  |  |  |  |  |
Granted |  |  | 2,201,800 |  | $ | 50.81 |  |  |  |  |  |  |
Exercised |  |  | (656,248 | ) | $ | 13.27 |  |  |  |  |  |  |
Forfeited |  |  | (152,047 | ) | $ | 49.58 |  |  |  |  |  |  |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2015 |  |  | 4,826,477 |  | $ | 37.20 |  |  | 8.38 years |  | $ | 32,391 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Vested or Expected to vest at December 31, 2015 |  |  | 3,266,769 |  | $ | 40.14 |  |  | 8.65 years |  | $ | 13,590 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Exercisable at December 31, 2015 |  |  | 1,357,478 |  | $ | 29.38 |  |  | 7.67 years |  | $ | 18,242 |
Schedule of assumptions used to estimate fair values of grants made on the date of grant |
|  | 2015 |  | 2014 |  | 2013
Risk-free interest rate |  | 1.48 - 2.18% |  | 0.11 - 2.04% |  | 0.85 - 1.90%
Expected volatility |  | 67 - 69% |  | 70 - 91% |  | 87 - 89%
Expected term |  | 5.50 - 9.12 years |  | 5.50 - 6.25 years |  | 6.00 - 6.25 years
Summary of information on the Company's restricted stock |
|  | Restricted Stock |
|  | Number of Shares |  | Weighted Average Grant Date Fair Value |
January 1, 2015 |  |  | 718,400 |  | $ | 10.72 |
Granted |  |  | — |  | $ | — |
Vested |  |  | (361,919 | ) | $ | 10.60 |
Forfeited |  |  | (12,146 | ) | $ | 10.84 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Unvested at December 31, 2015 |  |  | 344,335 |  | $ | 10.85 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of share-based compensation expense recorded in the statement of operations |
|  | Year ended December 31, |
|  | 2015 |  | 2014 |  | 2013 |
Research and development |  | $ | 16,138 |  | $ | 9,739 |  | $ | 4,312 |
Selling, general and administrative |  |  | 17,841 |  |  | 9,571 |  |  | 4,115 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total |  | $ | 33,979 |  | $ | 19,310 |  | $ | 8,427 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​

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