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v3.3.1.900

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Revenues: |  |  |
Net product revenue | $ 33,696 | $ 717 |
Collaboration and grant revenue | 3,070 | 24,528 | $ 34,696
Total revenues | 36,766 | 25,245 | 34,696
Operating expenses: |  |  |
Research and development | 121,816 | 79,838 | 54,875
Selling, general and administrative | 82,080 | 44,820 | 25,219
Total operating expenses | 203,896 | 124,658 | 80,094
Loss from operations | (167,130) | (99,413) | (45,398)
Interest (expense) income, net | (2,367) | 1,180 | (6,084)
Loss on extinguishment of debt |  |  | (130)
Other (expense) income, net | (465) | (213) | 38
Loss from operations before tax (expense) benefit | (169,962) | (98,446) | (51,574)
Income tax (expense) benefit | (485) | 4,693 |
Net loss | (170,447) | (93,753) | (51,574)
Deemed dividend |  |  | (18,249)
Gain on exchange of convertible preferred stock in connection with recapitalization |  |  | 3,391
Net loss attributable to common stockholders | $ (170,447) | $ (93,753) | $ (66,432)
Weighted-average shares outstanding: |  |  |
Basic and diluted (in shares) | 33,626,248.00 | 31,565,310.00 | 12,829,411.00
Net loss per share-basic and diluted (in dollars per share) |  |  |
Net loss per share-basic and diluted (in dollars per share) | $ (5.07) | $ (2.97) | $ (5.18)

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