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Income taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Current: |  |  |
Loss before income tax expense | $ (169,962) | $ (98,446) | $ (51,574)
U.S. State and local | (2) | 4,890 |
Foreign | (483) | (197) |
Current Income Tax Expense (Benefit), Total | $ (485) | $ 4,693 |
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate |  |  |
Federal income tax (benefit) at statutory rate (as a percent) | 34.00% | 34.00% | 34.00%
State income tax benefit, net of federal benefit (as a percent) | (0.43%) | (1.60%) | 5.65%
Permanent differences (as a percent) | (6.61%) | (0.93%) | (5.90%)
NOL IRC Section 382 Limitations (as a percent) |  | (21.53%) |
Research and development (as a percent) | 19.50% | 3.78% | 15.88%
Increase to valuation allowance (as a percent) | (20.87%) | 9.17% | (49.63%)
Foreign tax rate differential | (24.06%) | (18.14%) |
Other (as a percent) | (1.82%) | 0.01% |
Effective income tax rate (as a percent) | (0.29%) | 4.76% | 0.00%
Deferred tax assets: |  |  |
Accrued expense | $ 848 | $ 611 |
Amortization | 57 | 69 |
Depreciation | 2,631 | 2,268 |
Deferred revenue |  | 699 |
Federal tax credits | 50,850 | 17,807 |
State tax credits | 3,356 | 1,274 |
Federal net operating losses | 75,200 | 76,933 |
State net operating losses | 8,848 | 9,185 |
Capitalized research and development costs | 8,917 | 10,585 |
Other | 10,345 | 3,852 |
Total gross deferred tax assets | 161,052 | 123,283 |
Less valuation allowance | (139,584) | (123,283) |
Total deferred tax assets, net of valuation allowance | 21,468 |  |
Deferred tax liabilities: |  |  |
Convertible debt | (21,468) |  |
Total gross deferred tax liabilities | (21,468) |  |
Non US |  |  |
Current: |  |  |
Loss before income tax expense | 119,000 | 52,000 |
US |  |  |
Current: |  |  |
Loss before income tax expense | $ 51,000 | $ 46,500 |

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- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations applicable to state and local income tax expense (benefit), net of federal tax expense (benefit). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 6.I) -URI http://asc.fasb.org/extlink&oid=34349781&loc=d3e330036-122817 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32698-109319 + Details
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- Definition This element represents the income or loss from continuing operations attributable to the economic entity which may also be defined as revenue less expenses from ongoing operations, after income or loss from equity method investments, but before income taxes, extraordinary items, and noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 940 -SubTopic 20 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=35710027&loc=d3e41242-110953 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 10 -Article 5 + Details
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