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Fair value of financial instruments and investments (Tables) | 12 Months Ended
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Dec. 31, 2015
Fair value of financial instruments and investments |
Schedule of financial assets and liabilities that are required to be measured at fair value on a recurring basis |
|  | December 31, 2015 |
|  | Total |  | Quoted prices in active markets for identical assets (level 1) |  | Significant other observable inputs (level 2) |  | Significant unobservable inputs (level 3) |
Marketable securities |  | $ | 280,903 |  | $ | — |  | $ | 280,903 |  | $ | — |
Warrant liability |  |  | 48 |  |  | — |  |  | — |  |  | 48 |
|  | December 31, 2014 |
|  | Total |  | Quoted prices in active markets for identical assets (level 1) |  | Significant other observable inputs (level 2) |  | Significant unobservable inputs (level 3) |
Marketable securities |  | $ | 265,493 |  | $ | — |  | $ | 265,493 |  | $ | — |
Warrant Liability |  |  | 188 |  |  | — |  |  | — |  |  | 188 |
Summary of marketable securities accounted for as available-for-sale securities |
|  | December 31, 2015 |
|  |  |  | Gross Unrealized |  |  |
|  | Amortized Cost |  | Fair Value |
|  | Gains |  | Losses |
Commercial paper |  | $ | 26,877 |  | $ | 80 |  | $ | — |  | $ | 26,957 |
Corporate debt securities |  |  | 226,959 |  |  | — |  |  | (640 | ) |  | 226,319 |
Government obligations |  |  | 27,656 |  |  | 3 |  |  | (32 | ) |  | 27,627 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
|  | $ | 281,492 |  | $ | 83 |  | $ | (672 | ) | $ | 280,903 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
|  | December 31, 2014 |
|  |  |  | Gross Unrealized |  |  |
|  | Amortized Cost |  | Fair Value |
|  | Gains |  | Losses |
Corporate debt securities |  | $ | 230,379 |  | $ | 80 |  | $ | (428 | ) | $ | 230,031 |
Government obligations |  |  | 35,501 |  |  | 7 |  |  | (46 | ) |  | 35,462 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
|  | $ | 265,880 |  | $ | 87 |  | $ | (474 | ) | $ | 265,493 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Schedule of marketable securities on the balance sheet |
|  | December 31, 2015 |
|  | Less Than 12 Months |  | More Than 12 Months |
Commercial paper |  | $ | 26,957 |  | $ | — |
Corporate debt securities |  |  | 140,831 |  |  | 85,488 |
Government obligations |  |  | 18,994 |  |  | 8,633 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total Marketable securities |  | $ | 186,782 |  | $ | 94,121 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
|  | December 31, 2014 |
|  | Less Than 12 Months |  | More Than 12 Months |
Corporate debt securities |  | $ | 157,758 |  | $ | 72,273 |
Government obligations |  |  | 6,003 |  |  | 29,459 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Total Marketable securities |  | $ | 163,761 |  | $ | 101,732 |
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
Summary of changes in the fair value of the Company's Level 3 valuation for warrant liability |
|  | Level 3 assets |
Beginning balance as of January 1, 2014 |  | $ | 58 |
Change in fair value of warrant liability |  |  | 130 |
​ | ​ | ​ | ​ | ​
Ending balance as of December 31, 2014 |  | $ | 188 |
Change in fair value of warrant liability |  |  | (140 | )
​ | ​ | ​ | ​ | ​
Ending balance as of December 31, 2015 |  | $ | 48 |
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​ | ​ | ​ | ​ | ​

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- Definition Tabular disclosure of the fair value measurement of liabilities using significant unobservable inputs (Level 3), a reconciliation of the beginning and ending balances, separately presenting changes attributable to the following: (1) total gains or losses for the period (realized and unrealized), segregating those gains or losses included in earnings (or changes in net assets), and gains or losses recognized in other comprehensive income (loss) and a description of where those gains or losses included in earnings (or changes in net assets) are reported in the statement of income (or activities); (2) purchases, sales, issues, and settlements (each type disclosed separately); and (3) transfers in and transfers out of Level 3 (for example, transfers due to changes in the observability of significant inputs) by class of liability. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19279-110258 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Tabular disclosure of marketable securities. This may consist of investments in certain debt and equity securities, short-term investments and other assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6871852&loc=d3e26626-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03.4) -URI http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 5 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27232-111563 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6871852&loc=d3e26610-111562 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=27724398&loc=d3e27161-111563 Reference 6: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.2,12) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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- Definition Tabular disclosure of assets and liabilities, including [financial] instruments measured at fair value that are classified in stockholders' equity, if any, that are measured at fair value on a recurring basis. The disclosures contemplated herein include the fair value measurements at the reporting date by the level within the fair value hierarchy in which the fair value measurements in their entirety fall, segregating fair value measurements using quoted prices in active markets for identical assets (Level 1), significant other observable inputs (Level 2), and significant unobservable inputs (Level 3). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19190-110258 + Details
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