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Capital structure (Details 2) $ / shares in Units, $ in Thousands |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 16, 2014 USD ($) $ / shares shares | Mar. 07, 2013 USD ($) shares | Feb. 28, 2014 USD ($) $ / shares shares | Jun. 30, 2013 USD ($) $ / shares shares | May. 31, 2013 USD ($) $ / shares shares | Mar. 31, 2013 USD ($) | Dec. 31, 2013 USD ($) | Dec. 31, 2015 shares | Dec. 31, 2014 shares | Feb. 28, 2013 USD ($) $ / shares shares
Capital structure |  |  |  |  |  |  |  |  |  |
Gross proceeds raised | $ |  |  |  |  |  | $ 60,000 |  |  |  |
Gain on extinguishment of shares of Series One, Two and Three stock | $ |  |  |  |  |  |  | $ 3,391 |  |  |
Aggregate purchase price | $ |  |  |  |  |  |  | $ 131,650 |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Common stock, authorized shares |  |  |  |  |  |  |  | 125,000,000 | 125,000,000 |
Series One and Series Two | Warrants |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase shares |  |  |  |  |  |  |  |  |  | 2,527,675
Exercise price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  | $ 0.01
Shares issued and sold |  | 2,527,675 |  |  |  |  |  |  |  |
Series Four convertible preferred stock |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Shares issued and sold |  | 4,497,035 |  |  | 375,000 |  |  |  |  |
Aggregate gross proceeds | $ |  | $ 54,000 |  |  |  |  |  |  |  |
Share price (in dollars per share) | $ / shares |  |  |  |  | $ 12.00 |  |  |  |  |
Aggregate purchase price | $ |  |  |  |  | $ 4,500 |  |  |  |  |
Series Five convertible preferred stock |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Number of shares issued upon conversion |  | 6,700,487 |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Number of shares issued upon conversion |  | 6,700,487 |  |  |  |  |  |  |  |
Series Five convertible preferred stock | Warrants |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Number of shares issued upon conversion |  | 2,095,515 |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Number of shares issued upon conversion |  | 2,095,515 |  |  |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Shares issued and sold | 3,450,000 |  | 5,163,265 | 9,627,800 |  |  |  |  |  |
Reverse stock split ratio |  | 0.0083 |  |  |  |  |  |  |  |
Public offering price (in dollars per share) | $ / shares | $ 36.25 |  | $ 24.50 | $ 15.00 |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Common stock, authorized shares |  |  |  |  | 125,000,000 |  |  |  |  |
Common stock shares issuable pursuant to the exercise by the underwriters of an over-allotment option | 450,000 |  | 673,469 | 1,255,800 |  |  |  |  |  |
Net proceeds from public offerings | $ | $ 117,600 |  | $ 118,400 |  |  |  |  |  |  |
Net proceeds from initial public offering | $ |  |  |  | $ 131,600 |  |  |  |  |  |
Series Four and Series Five Convertible Preferred Stock |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Number of shares issuable upon conversion of each stock |  |  |  | 1 |  |  |  |  |  |
Number of shares issued upon conversion |  |  |  | 14,170,956 |  |  |  |  |  |
Common stock |  |  |  |  |  |  |  |  |  |
Number of shares issued upon conversion |  |  |  | 14,170,956 |  |  |  |  |  |
Convertible promissory notes |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Principal amount of Notes | $ |  |  |  |  |  |  |  |  |  | $ 6,000
Debt discount recorded to interest expense | $ |  |  |  |  |  | 6,000 |  |  |  |
Amount raised in bridge financing | $ |  |  |  |  |  | $ 6,000 |  |  |  |
Convertible promissory notes | Series Four convertible preferred stock |  |  |  |  |  |  |  |  |  |
Capital structure |  |  |  |  |  |  |  |  |  |
Shares issued upon conversion of convertible promissory notes |  | 502,919 |  |  |  |  |  |  |  |

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