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  <element id="ptct_CollaborationAndGrantRevenue" name="CollaborationAndGrantRevenue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_FirstFiveYearsMember" name="FirstFiveYearsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_ThereAfterFiveYearsMember" name="ThereAfterFiveYearsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DeferredTaxAssetsOperatingLossCarryforwardsPeriod" name="DeferredTaxAssetsOperatingLossCarryforwardsPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_OperatingLossCarryforwardsForImmediateUse" name="OperatingLossCarryforwardsForImmediateUse" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_OperatingLossCarryforwardsInNextTwelveMonths" name="OperatingLossCarryforwardsInNextTwelveMonths" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_EffectiveIncomeTaskRateReconciliationNetOperatingLossesLimitation" name="EffectiveIncomeTaskRateReconciliationNetOperatingLossesLimitation" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_NumberOfStatesInEuropeanEconomicArea" name="NumberOfStatesInEuropeanEconomicArea" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_ConvertibleSeniorNotes3.0PercentDue2022Member" name="ConvertibleSeniorNotes3.0PercentDue2022Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DebtInstrumentConvertibleThresholdConsecutiveTradingDayPeriod" name="DebtInstrumentConvertibleThresholdConsecutiveTradingDayPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DebtInstrumentConvertibleThresholdSalePriceOfCommonStockConversionRateProductPercentageMaximum" name="DebtInstrumentConvertibleThresholdSalePriceOfCommonStockConversionRateProductPercentageMaximum" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" name="DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_ScheduleOfInterestExpenseRecognizedRelatedToConvertibleDebt" name="ScheduleOfInterestExpenseRecognizedRelatedToConvertibleDebt" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DebtInstrumentConversionPeriodOnOrAfterAugust202018Member" name="DebtInstrumentConversionPeriodOnOrAfterAugust202018Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_ConvertibleInstrumentsPrincipalAndUnpaidInterestPayableUponEventsOfDefault" name="ConvertibleInstrumentsPrincipalAndUnpaidInterestPayableUponEventsOfDefault" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DebtInstrumentConvertibleThresholdBusinessDays" name="DebtInstrumentConvertibleThresholdBusinessDays" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_MinimumPercentageOfDebtPrincipalAmountByInstrumentHolders" name="MinimumPercentageOfDebtPrincipalAmountByInstrumentHolders" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_NetDeferredTaxLiabilitiesConvertibleDebtInstruments" name="NetDeferredTaxLiabilitiesConvertibleDebtInstruments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_TermOfPlaceboControlledClinicalTrail" name="TermOfPlaceboControlledClinicalTrail" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_NumberOfPatientsTestedInPlaceboControlledClinicalTrail" name="NumberOfPatientsTestedInPlaceboControlledClinicalTrail" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_NumberOfCountries" name="NumberOfCountries" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_DeferredTaxLiabilitiesConvertibleDebt" name="DeferredTaxLiabilitiesConvertibleDebt" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_OperatingLossCarryforwardAssociatedWithExerciseOfStockOptionsAndVestingOfRestrictedStock" name="OperatingLossCarryforwardAssociatedWithExerciseOfStockOptionsAndVestingOfRestrictedStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_IncomeTaxExpenseBenefitOnRecognitionOfOperatingLossCarryforwardRelatedToShareBasedCompensation" name="IncomeTaxExpenseBenefitOnRecognitionOfOperatingLossCarryforwardRelatedToShareBasedCompensation" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_ExpectedInSecondQuarter2016Member" name="ExpectedInSecondQuarter2016Member" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_WellcomeTrustLimitedMember" name="WellcomeTrustLimitedMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_RocheAndSmaFoundationMember" name="RocheAndSmaFoundationMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_StockIssuedDuringPeriodValueNewIssuesIncludingPublicOfferings" name="StockIssuedDuringPeriodValueNewIssuesIncludingPublicOfferings" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="ptct_StockIssuedDuringPeriodSharesNewIssuesIncludingPublicOfferings" name="StockIssuedDuringPeriodSharesNewIssuesIncludingPublicOfferings" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>
