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Income taxes (Details 3) $ in Millions | 12 Months Ended
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Dec. 31, 2015 USD ($)
Credit carryforwards |
Orphan drug credit carryover | $ 39.8
Limited NOL carryforwards | 231.5
Operating loss carryforwards, not subject to expiration | $ 169.2
NOL carryforward period | 20 years
Operating loss carryforwards, subject to expiration | $ 62.3
Operating loss carryforwards for immediate use | 142.9
Operating loss carryforwards in next twelve months | 16.7
Federal |
Credit carryforwards |
Research and development credit carryforwards | 11.0
Net operating loss carryforwards | 270.4
State |
Credit carryforwards |
Research and development credit carryforwards | 4.8
Net operating loss carryforwards | 198.1
First five years from ownership change |
Credit carryforwards |
Net operating loss carryforwards | 16.7
After five years |
Credit carryforwards |
Net operating loss carryforwards | $ 5.7

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