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Fair value of financial instruments and marketable securities (Details 4) - Warrants - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended
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Dec. 31, 2015 | Dec. 31, 2014
Changes in the fair value of warrant liability |  |
Beginning balance | $ 188 | $ 58
Change in fair value of warrant liability | (140) | 130
Ending balance | $ 48 | $ 188
Minimum |  |
Assumption used to estimate the fair value of warrant liability by utilizing the Black-Scholes option-pricing model |  |
Volatility (as a percent) | 62.00% | 68.00%
Risk-free interest rate (as a percent) | 0.86% | 0.89%
Strike price (in dollars per share) | $ 128.00 | $ 128.00
Expected life | 1 year 6 months | 2 years 6 months
Maximum |  |
Assumption used to estimate the fair value of warrant liability by utilizing the Black-Scholes option-pricing model |  |
Volatility (as a percent) | 70.00% | 70.00%
Risk-free interest rate (as a percent) | 1.54% | 1.65%
Strike price (in dollars per share) | $ 2,520.00 | $ 2,520.00
Expected life | 3 years 8 months 12 days | 4 years 8 months 12 days
Common stock |  |
Assumption used to estimate the fair value of warrant liability by utilizing the Black-Scholes option-pricing model |  |
Fair value of shares (in dollars per share) | $ 32.40 | $ 51.77

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- Definition Agreed upon price for the exchange of the underlying asset. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Period the instrument, asset or liability is expected to be outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Measure of dispersion, in percentage terms (for instance, the standard deviation or variance), for a given stock price. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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- Definition Amount of gain (loss) recognized on the income statement for financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=36462937&loc=d3e19207-110258 + Details
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