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Selected quarterly financial data (Unaudited)

12 Months Ended

Dec. 31, 2015

Selected quarterly financial data (Unaudited)

Selected quarterly financial data (Unaudited)

17. Selected quarterly financial data (Unaudited)

        The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2015 and 2014 are as follows:

		For the quarters ending
		March 31			June 30			September 30			December 31
2015:
Net product revenue		$	5,069		$	6,161		$	9,772		$	12,694
Collaboration and grant revenue			2,413			613			4			40
Operating expenses			45,553			45,400			52,008			60,935
Loss from operations			(38,071	)		(38,626	)		(42,232	)		(48,201	)
Net loss			(37,915	)		(38,361	)		(43,223	)		(50,948	)
Basic and diluted net loss per common share(1)		$	(1.15	)	$	(1.14	)	$	(1.27	)	$	(1.50	)
2014:
Net product revenue		$	—		$	—		$	81		$	636
Collaboration and grant revenue			9,217			1,677			1,613			12,022
Operating expenses			23,429			27,046			29,295			44,888
Loss from operations			(14,212	)		(25,369	)		(27,601	)		(32,230	)
Net loss			(14,098	)		(25,104	)		(27,282	)		(27,269	)
Basic and diluted net loss per common share(1)		$	(0.58	)	$	(0.86	)	$	(0.93	)	$	(0.84	)

(1)           The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.

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- References

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- Definition

The entire disclosure for the quarterly financial data in the annual financial statements. The disclosure may include a tabular presentation of financial information for each fiscal quarter for the current and previous year, including revenues, gross profit, income or loss before extraordinary items and earnings per share data. It also includes an indication if the information in the note is unaudited, comments on the aggregate effect of year-end adjustments, and an explanation of matters or transactions that affect comparability or are pertinent to an understanding of the information furnished.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section 45
-Paragraph 13
-URI http://asc.fasb.org/extlink&oid=6372559&loc=d3e765-108305

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)-(j)
-URI http://asc.fasb.org/extlink&oid=35737889&loc=d3e1280-108306

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 270
-SubTopic 10
-Section 45
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=6372559&loc=d3e725-108305

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 6
-Section G
-Subsection 1

Reference 5: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-K (SK)
-Number 229
-Section 302
-Paragraph a

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