XML 48 R33.htm IDEA: XBRL DOCUMENT v3.3.1.900

Stock award plan (Tables)

12 Months Ended

Dec. 31, 2015

Stock award plan

Summary of stock option activity

Number of options

Weighted- average exercise price

Weighted- average remaining contractual term

Aggregate intrinsic value

(in thousands)

Outstanding at December 31, 2012

42,394

$

474.00

Granted

2,117,113

$

11.29

Exercised

—

$

—

Forfeited

(63,915

)

$

12.57

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2013

2,095,592

$

20.24

Granted

1,639,996

$

31.09

Exercised

(108,645

)

$

11.00

Forfeited

(193,971

)

$

32.91

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2014

3,432,972

$

25.00

Granted

2,201,800

$

50.81

Exercised

(656,248

)

$

13.27

Forfeited

(152,047

)

$

49.58

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Outstanding at December 31, 2015

4,826,477

$

37.20

8.38 years

$

32,391

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Vested or Expected to vest at December 31, 2015

3,266,769

$

40.14

8.65 years

$

13,590

​

​

​

​

​

​

​

​

​

​

​

​

​

​

Exercisable at December 31, 2015

1,357,478

$

29.38

7.67 years

$

18,242

Schedule of assumptions used to estimate fair values of grants made on the date of grant

		2015		2014		2013
Risk-free interest rate		1.48 - 2.18%		0.11 - 2.04%		0.85 - 1.90%
Expected volatility		67 - 69%		70 - 91%		87 - 89%
Expected term		5.50 - 9.12 years		5.50 - 6.25 years		6.00 - 6.25 years

Summary of information on the Company's restricted stock

		Restricted Stock
		Number of Shares			Weighted Average Grant Date Fair Value
January 1, 2015			718,400		$	10.72
Granted			—		$	—
Vested			(361,919	)	$	10.60
Forfeited			(12,146	)	$	10.84
​	​	​	​	​	​	​	​
Unvested at December 31, 2015			344,335		$	10.85
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​

Schedule of share-based compensation expense recorded in the statement of operations

		Year ended December 31,
		2015			2014			2013
Research and development		$	16,138		$	9,739		$	4,312
Selling, general and administrative			17,841			9,571			4,115
​	​	​	​	​	​	​	​	​	​	​
Total		$	33,979		$	19,310		$	8,427
​	​	​	​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​	​	​	​

X

- References

No definition available.

+ Details

Name:	us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the changes in outstanding nonvested restricted stock shares.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_NonvestedRestrictedStockSharesActivityTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 14.F)
-URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Staff Accounting Bulletin (SAB)
-Number Topic 14
-Section F

+ Details

Name:	us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

+ Details

Name:	us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration