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Income taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income taxes

Components of Income Tax Provision

		2015			2014
Current:
U.S. Federal		$	—		$	—
U.S. State and Local			(2)			4,890
Foreign			(483)			(197)
​	​	​	​	​	​	​	​
		$	(485)		$	4,693
​	​	​	​	​	​	​	​
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Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate

		December 31,
		2015			2014			2013
Federal income tax (benefit) at statutory rate			34.00	%		34.00	%		34.00	%
State income tax benefit, net of federal benefit			(0.43	)		(1.60	)		5.65
Permanent differences			(6.61	)		(0.93	)		(5.90	)
NOL IRC Section 382 Limitations			—			(21.53	)		—
Research and development			19.50			3.78			15.88
Increase to valuation allowance			(20.87	)		9.17			(49.63	)
Foreign tax rate differential			(24.06	)		(18.14	)		—
Other			(1.82	)		0.01			—
​	​	​	​	​	​	​	​	​	​	​
Effective income tax rate			(0.29	)%		4.76	%		0.00	%
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Schedule of significant components of the Company's deferred tax assets and liabilities

		2015			2014
Deferred tax assets:
Accrued Expense		$	848		$	611
Amortization			57			69
Depreciation			2,631			2,268
Deferred revenue			—			699
Federal tax credits			50,850			17,807
State tax credits			3,356			1,274
Federal net operating losses			75,200			76,933
State net operating losses			8,848			9,185
Capitalized research and development costs			8,917			10,585
Other			10,345			3,852
​	​	​	​	​	​	​	​
Total gross deferred tax assets			161,052			123,283
Less valuation allowance			(139,584	)		(123,283	)
​	​	​	​	​	​	​	​
Total deferred tax assets, net of valuation allowance		$	21,468		$	—
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​
Deferred tax liabilities:
Convertible debt		$	(21,468	)	$	—
​	​	​	​	​	​	​	​
Total gross deferred tax assets			(21,468	)		—
​	​	​	​	​	​	​	​
Net deferred tax assets (liabilities)		$	—		$	—
​	​	​	​	​	​	​	​
​	​	​	​	​	​	​	​

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- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
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