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Selected quarterly financial data (Tables)
 12 Months Ended
Dec. 31, 2015
Selected quarterly financial data (Unaudited)  
Summary of quarterly data

 

                                                                                                                                                                                    

 

 

For the quarters ending

 

 

 

March 31

 

June 30

 

September 30

 

December 31

 

2015:

 

 

 

 

 

 

 

 

 

 

 

 

 

Net product revenue

 

$
5,069

 

$
6,161

 

$
9,772

 

$
12,694

 

Collaboration and grant revenue

 

 
2,413

 

 
613

 

 
4

 

 
40

 

Operating expenses

 

 
45,553

 

 
45,400

 

 
52,008

 

 
60,935

 

Loss from operations

 

 
(38,071

)

 
(38,626

)

 
(42,232

)

 
(48,201

)

Net loss

 

 
(37,915

)

 
(38,361

)

 
(43,223

)

 
(50,948

)

Basic and diluted net loss per common share(1)

 

$
(1.15

)

$
(1.14

)

$
(1.27

)

$
(1.50

)

2014:

 

 

 

 

 

 

 

 

 

 

 

 

 

Net product revenue

 

$

—

 

$

—

 

$
81

 

$
636

 

Collaboration and grant revenue

 

 
9,217

 

 
1,677

 

 
1,613

 

 
12,022

 

Operating expenses

 

 
23,429

 

 
27,046

 

 
29,295

 

 
44,888

 

Loss from operations

 

 
(14,212

)

 
(25,369

)

 
(27,601

)

 
(32,230

)

Net loss

 

 
(14,098

)

 
(25,104

)

 
(27,282

)

 
(27,269

)

Basic and diluted net loss per common share(1)

 

$
(0.58

)

$
(0.86

)

$
(0.93

)

$
(0.84

)

 

 

 

(1)          

The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.