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The Company (Detail)
$ in Thousands
1 Months Ended 12 Months Ended
Aug. 04, 2014
Aug. 31, 2014
state
item
Dec. 31, 2015
USD ($)
country
Aug. 31, 2015
Dec. 31, 2014
USD ($)
Minimum age of ambulatory patient 5 years 5 years      
Number of States In European Economic Area | state   31      
Period of placebo controlled clinical trail   336 days      
Number of patients tested in placebo controlled clinical trail | item   174      
Number of countries made availability of Translama on a commercial basis | country     17    
Accumulated deficit. | $     $ (592,998)   $ (422,551)
3.00% Convertible senior notes due 2022 | Convertible debt          
Interest rate       3.00%