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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Revenues:      
Net product revenue $ 33,696 $ 717  
Collaboration and grant revenue 3,070 24,528 $ 34,696
Total revenues 36,766 25,245 34,696
Operating expenses:      
Research and development 121,816 79,838 54,875
Selling, general and administrative 82,080 44,820 25,219
Total operating expenses 203,896 124,658 80,094
Loss from operations (167,130) (99,413) (45,398)
Interest (expense) income, net (2,367) 1,180 (6,084)
Loss on extinguishment of debt     (130)
Other (expense) income, net (465) (213) 38
Loss from operations before tax (expense) benefit (169,962) (98,446) (51,574)
Income tax (expense) benefit (485) 4,693  
Net loss (170,447) (93,753) (51,574)
Deemed dividend     (18,249)
Gain on exchange of convertible preferred stock in connection with recapitalization     3,391
Net loss attributable to common stockholders $ (170,447) $ (93,753) $ (66,432)
Weighted-average shares outstanding:      
Basic and diluted (in shares) 33,626,248.00 31,565,310.00 12,829,411.00
Net loss per share-basic and diluted (in dollars per share)      
Net loss per share-basic and diluted (in dollars per share) $ (5.07) $ (2.97) $ (5.18)