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Summary of significant accounting policies (Details 2)
$ in Thousands
1 Months Ended 12 Months Ended
Aug. 04, 2014
state
Aug. 31, 2014
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Research and development costs        
Minimum age of Ambulatory Patient 5 years 5 years    
Number of States | state 31      
Deferred research and development advance payments     $ 600 $ 900
Impairment of long-lived assets        
Impairment of long-lived assets     0  
Income Tax Expense (Benefit), Continuing Operations        
Income tax (expense) benefit     (485) 4,693
Recent accounting pronouncements        
Unamortized debt issuance cost     $ 2,800  
New Jersey        
Income Tax Expense (Benefit), Continuing Operations        
Income tax (expense) benefit       $ 4,900