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Fixed assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Fixed assets
Gross fixed assets	$ 36,676	$ 34,076
Less accumulated depreciation and amortization	(27,702)	(24,917)
Net fixed assets	8,974	9,159
Depreciation expense	2,876	2,235	$ 2,396
Leasehold improvements
Fixed assets
Gross fixed assets	14,029	13,051
Computer equipment and software
Fixed assets
Gross fixed assets	4,102	2,472
Furniture, fixtures, and lab equipment
Fixed assets
Gross fixed assets	17,443	15,070
Assets in process
Fixed assets
Gross fixed assets	$ 1,102	$ 3,483

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (c)
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Reference 2: http://www.xbrl.org/2003/role/presentationRef
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-Topic 210
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-Section S99
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-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 02
-Paragraph 14
-Article 5

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- Definition

The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 360
-SubTopic 10
-Section 50
-Paragraph 1
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-URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229

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-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.13)
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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-Publisher SEC
-Name Regulation S-X (SX)
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