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Accounts payable and accrued expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Accounts payable and accrued expenses
Employee compensation, benefits, and related accruals	$ 11,187	$ 9,312
Consulting and contracted research	13,753	9,349
Professional fees	2,523	3,334
Accounts payable	11,940	4,128
Other	5,844	2,998
Accounts payable and accrued expenses	$ 45,247	$ 29,121

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- Definition

Represents the carrying value as of the balance sheet date of obligations incurred through that date and payable for consulting and contracted research.

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Sum of the carrying values as of the balance sheet date of obligations incurred through that date and due within one year (or the operating cycle, if longer), including liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received, taxes, interest, rent and utilities, accrued salaries and bonuses, payroll taxes and fringe benefits.

+ References

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Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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