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Earnings per share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Net loss per share
Total shares excluded from calculation									5,170,812	4,151,372	3,205,818
Numerator
Net loss	$ (50,948)	$ (43,223)	$ (38,361)	$ (37,915)	$ (27,269)	$ (27,282)	$ (25,104)	$ (14,098)	$ (170,447)	$ (93,753)	$ (51,574)
Deemed dividend											(18,249)
Gain on exchange of convertible preferred stock in connection with recapitalization											3,391
Net loss attributable to common stockholders									$ (170,447)	$ (93,753)	$ (66,432)
Denominator
Denominator for basic and diluted net loss per share (in shares)									33,626,248.00	31,565,310.00	12,829,411.00
Net loss per share:
Basic and diluted (in dollars per share)	$ (1.50)	$ (1.27)	$ (1.14)	$ (1.15)	$ (0.84)	$ (0.93)	$ (0.86)	$ (0.58)	$ (5.07)	$ (2.97)	$ (5.18)
Stock options
Net loss per share
Total shares excluded from calculation									4,826,477	3,432,972	2,095,592
Restricted stock
Net loss per share
Total shares excluded from calculation									344,335	718,400	1,110,226

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