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Collaborations and grants (Details)
$ in Millions
1 Months Ended 12 Months Ended
Jan. 02, 2011
item
Nov. 30, 2014
USD ($)
Jan. 31, 2014
USD ($)
Nov. 30, 2011
USD ($)
item
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Minimum              
Grant revenue              
Term of grant program         2 years    
Maximum              
Grant revenue              
Term of grant program         5 years    
Collaboration agreement | Development event milestones              
Collaborations and grants              
Collaboration revenue recognized   $ 10.0 $ 7.5        
Collaboration agreement | Roche and SMA Foundation [Member]              
Collaborations and grants              
Number of compounds in preclinical development | item       3      
Deferred revenue       $ 30.0      
Number of significant deliverables | item       2      
Research period for applying technology       2 years      
Collaboration revenue recognized         $ 0.6 $ 20.2 $ 26.6
Collaboration agreement | Roche and SMA Foundation [Member] | Development event milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         135.0    
Collaboration agreement | Roche and SMA Foundation [Member] | Sales milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         325.0    
Early stage collaboration and discovery agreements              
Collaborations and grants              
Deferred revenue         0.0 1.8  
Number of significant deliverables | item 2            
Collaboration revenue recognized         $ 1.8 $ 1.3  
Early stage collaboration and discovery agreements | Minimum              
Collaborations and grants              
Research period for applying technology         3 years    
Early stage collaboration and discovery agreements | Maximum              
Collaborations and grants              
Research period for applying technology         4 years    
Early stage collaboration and discovery agreements | Development event milestones              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         $ 143.0    
Early stage collaboration and discovery agreements | Sales milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         $ 252.0