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Income taxes (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Current:      
Loss before income tax expense $ (169,962) $ (98,446) $ (51,574)
U.S. State and local (2) 4,890  
Foreign (483) (197)  
Current Income Tax Expense (Benefit), Total $ (485) $ 4,693  
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate      
Federal income tax (benefit) at statutory rate (as a percent) 34.00% 34.00% 34.00%
State income tax benefit, net of federal benefit (as a percent) (0.43%) (1.60%) 5.65%
Permanent differences (as a percent) (6.61%) (0.93%) (5.90%)
NOL IRC Section 382 Limitations (as a percent)   (21.53%)  
Research and development (as a percent) 19.50% 3.78% 15.88%
Increase to valuation allowance (as a percent) (20.87%) 9.17% (49.63%)
Foreign tax rate differential (24.06%) (18.14%)  
Other (as a percent) (1.82%) 0.01%  
Effective income tax rate (as a percent) (0.29%) 4.76% 0.00%
Deferred tax assets:      
Accrued expense $ 848 $ 611  
Amortization 57 69  
Depreciation 2,631 2,268  
Deferred revenue   699  
Federal tax credits 50,850 17,807  
State tax credits 3,356 1,274  
Federal net operating losses 75,200 76,933  
State net operating losses 8,848 9,185  
Capitalized research and development costs 8,917 10,585  
Other 10,345 3,852  
Total gross deferred tax assets 161,052 123,283  
Less valuation allowance (139,584) (123,283)  
Total deferred tax assets, net of valuation allowance 21,468    
Deferred tax liabilities:      
Convertible debt (21,468)    
Total gross deferred tax liabilities (21,468)    
Non US      
Current:      
Loss before income tax expense 119,000 52,000  
US      
Current:      
Loss before income tax expense $ 51,000 $ 46,500