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Consolidated Statements of Convertible Preferred Stock and Changes in Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Series One-Three convertible preferred stock
Series Four convertible preferred stock
Series Five convertible preferred stock
Common stock
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Total
Balance, beginning of period at Dec. 31, 2012 $ 80,824              
Balance, beginning of period (in shares) at Dec. 31, 2012 15,038,259              
Increase (decrease) in temporary equity                
Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock $ (80,824) $ 60,785 $ 101,682          
Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock (in shares) (15,038,259) 5,374,954 8,796,002          
Conversion of series of convertible preferred stock to common stock   $ (60,785) $ (101,682)          
Conversion of series of convertible preferred stock to common stock (in shares)   (5,374,954) (8,796,002)          
Balance at Dec. 31, 2012         $ 177,584   $ (277,224) $ (99,640)
Balance (in shares) at Dec. 31, 2012       545,345        
Increase (Decrease) in Stockholders' Equity                
Reverse stock split       (540,819)        
Issuance and exchange of series of convertible preferred stock for series of convertible preferred stock         (14,858)     (14,858)
Issuance of common stock from IPO and exercise of over allotment exercise, net of offering costs       $ 10 131,640     131,650
Issuance of common stock from IPO and exercise of over allotment exercise, net of offering costs (in shares)       9,627,800        
Conversion of series of convertible preferred stock to common stock       $ 14 162,453     162,467
Conversion of series of convertible preferred stock to common stock (in shares)       14,170,956        
Share-based compensation expense         8,427     8,427
Net loss             (51,574) (51,574)
Comprehensive income (loss)           $ 70   70
Balance at Dec. 31, 2013       $ 24 465,246 70 (328,798) 136,542
Balance (in shares) at Dec. 31, 2013       23,803,282        
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs       $ 9 235,971     235,980
Issuance of common stock from public offerings and exercise of over allotment exercise, net of offering costs (in shares)       8,613,265        
Exercise of stock options         1,195     1,195
Exercise of stock options (in shares)       108,645        
Restricted stock vesting (in shares)       373,200        
Share-based compensation expense         19,310     19,310
Net loss             (93,753) (93,753)
Comprehensive income (loss)           (807)   (807)
Balance at Dec. 31, 2014       $ 33 721,722 (737) (422,551) 298,467
Balance (in shares) at Dec. 31, 2014       32,898,392        
Increase (Decrease) in Stockholders' Equity                
Equity component of the convertible notes issuance, net         57,538     57,538
Debt Issuance Cost         (1,784)     (1,784)
Exercise of stock options       $ 1 8,710     8,711
Exercise of stock options (in shares)       656,248        
Restricted stock vesting (in shares)       361,919        
Share-based compensation expense         33,979     33,979
Net loss             (170,447) (170,447)
Comprehensive income (loss)           (463)   (463)
Balance at Dec. 31, 2015       $ 34 $ 820,165 $ (1,200) $ (592,998) $ 226,001
Balance (in shares) at Dec. 31, 2015       33,916,559