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Income taxes (Details 3)
$ in Millions
 12 Months Ended
Dec. 31, 2015
USD ($)
Credit carryforwards  
Orphan drug credit carryover $ 39.8
Limited NOL carryforwards 231.5
Operating loss carryforwards, not subject to expiration $ 169.2
NOL carryforward period 20 years
Operating loss carryforwards, subject to expiration $ 62.3
Operating loss carryforwards for immediate use 142.9
Operating loss carryforwards in next twelve months 16.7
Federal  
Credit carryforwards  
Research and development credit carryforwards 11.0
Net operating loss carryforwards 270.4
State  
Credit carryforwards  
Research and development credit carryforwards 4.8
Net operating loss carryforwards 198.1
First five years from ownership change  
Credit carryforwards  
Net operating loss carryforwards 16.7
After five years  
Credit carryforwards  
Net operating loss carryforwards $ 5.7