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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Selected quarterly financial data (Unaudited)
Net product revenue	$ 12,694	$ 9,772	$ 6,161	$ 5,069	$ 636	$ 81			$ 33,696	$ 717
Collaboration and grant revenue	40	4	613	2,413	12,022	1,613	$ 1,677	$ 9,217	3,070	24,528	$ 34,696
Operating expenses	60,935	52,008	45,400	45,553	44,888	29,295	27,046	23,429	203,896	124,658	80,094
Loss from operations	(48,201)	(42,232)	(38,626)	(38,071)	(32,230)	(27,601)	(25,369)	(14,212)	(167,130)	(99,413)	(45,398)
Net loss	$ (50,948)	$ (43,223)	$ (38,361)	$ (37,915)	$ (27,269)	$ (27,282)	$ (25,104)	$ (14,098)	(170,447)	(93,753)	(51,574)
Deemed dividend											18,249
Gain on exchange of convertible preferred stock in connection with recapitalization											3,391
Net loss attributable to common stockholders									$ (170,447)	$ (93,753)	$ (66,432)
Net loss per share-basic and diluted (in dollars per share)	$ (1.50)	$ (1.27)	$ (1.14)	$ (1.15)	$ (0.84)	$ (0.93)	$ (0.86)	$ (0.58)	$ (5.07)	$ (2.97)	$ (5.18)

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Amount of revenue earned from collaborative research and development and licensing agreements and non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
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