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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities      
Net loss $ (170,447) $ (93,753) $ (51,574)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 2,876 2,235 2,396
Change in valuation of warrant liability (140) 130 (38)
Amortization of premiums on investments 2,480 1,607  
Amortization of debt issuance costs 107    
Share-based compensation expense 33,979 19,310 8,427
Non-cash interest expense 2,146   6,049
Loss on extinguishment of debt     130
Disposal of asset (37)    
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets (2,107) (2,286) (760)
Trade receivables, net (6,907) (3,487) 56
Deposits and other assets 131 (340) 48
Accounts payable and accrued expenses 16,981 16,914 5,183
Other long-term liabilities (92) (80) (285)
Deferred revenue (3,307) 2,476 (16,554)
Net cash used in operating activities (124,337) (57,274) (46,922)
Cash flows from investing activities      
Purchases of fixed assets (2,720) (4,664) (846)
Purchases of marketable securities (223,762) (247,804) (156,045)
Sale & redemptions of marketable securities 205,671 107,300 29,062
Net cash used in investing activities (20,811) (145,168) (127,829)
Cash flows from financing activities      
Payments on long-term debt   (49) (4,996)
Net proceeds from sale of Series Four preferred stock     60,785
Proceeds from exercise of options 8,711 1,196  
Net proceeds from public offerings   235,979 131,650
Debt issuance costs related to convertible notes (4,650)    
Proceeds from issuance of convertible notes 150,000    
Net cash provided by financing activities 154,061 237,126 187,439
Effect of exchange rate changes on cash (639) (350)  
Net increase in cash and cash equivalents 8,274 34,334 12,688
Cash and cash equivalents, beginning of period 49,748 15,414 2,726
Cash and cash equivalents, end of period 58,022 49,748 15,414
Supplemental disclosure of cash information      
Cash paid for interest   1 367
Cash paid for income taxes 111   2
Supplemental disclosures of non-cash information related to investing and financing activities      
Change in unrealized (loss) gain on marketable securities $ (202) $ (457) 70
Change in carry value of preferred securities resulting from recapitalization     $ 3,391