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Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Revenues:    
Net product revenue $ 18,878 $ 5,069
Collaboration and grant revenue 17 2,413
Total revenues 18,895 7,482
Operating expenses:    
Research and development 31,399 27,938
Selling, general and administrative 25,938 17,615
Total operating expenses 57,337 45,553
Loss from operations (38,442) (38,071)
Interest (expense) income, net (1,956) 524
Other expense, net (721) (368)
Loss before income tax expense (41,119) (37,915)
Income tax expense (114)  
Net loss attributable to common stockholders $ (41,233) $ (37,915)
Weighted-average shares outstanding:    
Basic and diluted (in shares) 33,919,169 33,067,752
Net loss per share-basic and diluted (in dollars per share)    
Net loss per share-basic and diluted (in dollars per share) $ (1.22) $ (1.15)