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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Cash flows from operating activities    
Net loss $ (41,233) $ (37,915)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 849 634
Change in valuation of warrant liability (47) 41
Non-cash interest expense 1,446  
Amortization of premiums on investments 631 486
Amortization of debt issuance costs 72  
Share-based compensation expense 8,915 9,748
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 702 (2,231)
Trade receivables, net (10,678) 1,267
Deposits and other assets (12) 138
Accounts payable and accrued expenses (2,452) (5,589)
Other long-term liabilities (23) (23)
Deferred revenue 243 (2,981)
Net cash used in operating activities (41,587) (36,425)
Cash flows from investing activities    
Purchases of fixed assets (265) (883)
Purchases of marketable securities (19,413) (19,108)
Sale & redemption of marketable securities 41,795 40,598
Net cash provided by investing activities 22,117 20,607
Cash flows from financing activities    
Proceeds from exercise of options 34 3,019
Net cash provided by financing activities 34 3,019
Effect of exchange rate changes on cash 1,579 (124)
Net decrease in cash and cash equivalents (17,857) (12,923)
Cash and cash equivalents, beginning of period 58,022 49,748
Cash and cash equivalents, end of period 40,165 36,825
Supplemental disclosure of cash information    
Cash paid for interest 2,263  
Cash paid for income taxes 225  
Supplemental disclosures of non-cash information related to investing and financing activities    
Change in unrealized gain on marketable securities $ 658 $ 125