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Consolidated Statements of Operations - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Revenues:        
Net product revenue $ 15,437 $ 6,161 $ 34,314 $ 11,230
Collaboration and grant revenue 196 613 214 3,026
Total revenues 15,633 6,774 34,528 14,256
Operating expenses:        
Research and development 28,827 28,190 60,226 56,128
Selling, general and administrative 23,366 17,210 49,304 34,825
Total operating expenses 52,193 45,400 109,530 90,953
Loss from operations (36,560) (38,626) (75,002) (76,697)
Interest (expense) income, net (2,060) 498 (4,016) 1,022
Other expense, net (387) (88) (1,107) (456)
Loss before income tax expense (39,007) (38,216) (80,125) (76,131)
Income tax benefit (expense) 93 (145) (22) (145)
Net loss attributable to common stockholders $ (38,914) $ (38,361) $ (80,147) $ (76,276)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 34,000,333 33,600,653 33,959,751 33,335,674
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share-basic and diluted (in dollars per share) $ (1.14) $ (1.14) $ (2.36) $ (2.29)