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The Company (Details) $ in Thousands | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2014 state | Sep. 30, 2016 USD ($) | Dec. 31, 2015 USD ($) | Aug. 31, 2015
Long-term debt |  |  |  |
Minimum age of ambulatory patient | 5 years |  |  |
Number of member states of the European Economic Area | state | 31 |  |  |
Accumulated deficit | $ |  | $ (708,313) | $ (592,998) |
Convertible debt | 3.00% Convertible senior notes due 2022 |  |  |  |
Long-term debt |  |  |  |
Interest rate |  |  |  | 3.00%

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