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Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015
Revenues: |  |  |  |
Net product revenue | $ 22,013 | $ 9,772 | $ 56,328 | $ 21,002
Collaboration and grant revenue | 973 | 4 | 1,186 | 3,030
Total revenues | 22,986 | 9,776 | 57,514 | 24,032
Operating expenses: |  |  |  |
Research and development | 31,396 | 30,640 | 91,622 | 86,768
Selling, general and administrative | 23,654 | 21,368 | 72,958 | 56,193
Total operating expenses | 55,050 | 52,008 | 164,580 | 142,961
Loss from operations | (32,064) | (42,232) | (107,066) | (118,929)
Interest (expense) income, net | (2,133) | (852) | (6,149) | 170
Other expense, net | (786) | (51) | (1,893) | (507)
Loss before income tax expense | (34,983) | (43,135) | (115,108) | (119,266)
Income tax expense | (184) | (88) | (206) | (233)
Net loss attributable to common stockholders | $ (35,167) | $ (43,223) | $ (115,314) | $ (119,499)
Weighted-average shares outstanding: |  |  |  |
Basic and diluted (in shares) | 34,088,741 | 33,908,853 | 34,002,952 | 33,528,833
Net loss per share-basic and diluted (in dollars per share) |  |  |  |
Net loss per share—basic and diluted (in dollars per share) | $ (1.03) | $ (1.27) | $ (3.39) | $ (3.56)

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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