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The Company (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2014 state	Sep. 30, 2016 USD ($)	Dec. 31, 2015 USD ($)	Aug. 31, 2015
Long-term debt
Minimum age of ambulatory patient	5 years
Number of member states of the European Economic Area | state	31
Accumulated deficit | $		$ (708,313)	$ (592,998)
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Interest rate				3.00%

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- Definition

Represents the number of states in European economic area.

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- Definition

Contractual interest rate for funds borrowed, under the debt agreement.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.22(a)(1))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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- Definition

The cumulative amount of the reporting entity's undistributed earnings or deficit.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.31(a)(3))
-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher SEC
-Name Regulation S-X (SX)
-Number 210
-Section 04
-Article 3

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