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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Revenues:        
Net product revenue $ 22,013 $ 9,772 $ 56,328 $ 21,002
Collaboration and grant revenue 973 4 1,186 3,030
Total revenues 22,986 9,776 57,514 24,032
Operating expenses:        
Research and development 31,396 30,640 91,622 86,768
Selling, general and administrative 23,654 21,368 72,958 56,193
Total operating expenses 55,050 52,008 164,580 142,961
Loss from operations (32,064) (42,232) (107,066) (118,929)
Interest (expense) income, net (2,133) (852) (6,149) 170
Other expense, net (786) (51) (1,893) (507)
Loss before income tax expense (34,983) (43,135) (115,108) (119,266)
Income tax expense (184) (88) (206) (233)
Net loss attributable to common stockholders $ (35,167) $ (43,223) $ (115,314) $ (119,499)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 34,088,741 33,908,853 34,002,952 33,528,833
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share—basic and diluted (in dollars per share) $ (1.03) $ (1.27) $ (3.39) $ (3.56)