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Commitments and contingencies (Details) - USD ($) $ in Millions | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Jan. 31, 2017 | Jun. 30, 2016
Other contingencies |  |  |  |  |
Operating leases, rent expense | $ 2.2 | $ 1.8 | $ 0.9 |  |
Funding agreement | Wellcome trust limited |  |  |  |  |
Other contingencies |  |  |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay |  |  |  |  | $ 0.8
Subsequent Event | Funding agreement | Maximum | Wellcome trust limited |  |  |  |  |
Other contingencies |  |  |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay |  |  |  | $ 22.4 |

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- Definition Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6453985&loc=d3e41499-112717 + Details
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