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Selected quarterly financial data (Tables) | 12 Months Ended
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Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract] |
Summary of quarterly data | The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2016 and 2015 are as follows:
|  | For the quarters ending
|  | March 31 |  | June 30 |  | September 30 |  | December 31
2016: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 18,878 |  |  | $ | 15,437 |  |  | $ | 22,013 |  |  | $ | 25,119 |
Collaboration and grant revenue |  | 17 |  |  | 196 |  |  | 973 |  |  | 72 |
Operating expenses |  | 57,337 |  |  | 52,193 |  |  | 55,050 |  |  | 50,183 |
Loss from operations |  | (38,442 | ) |  | (36,560 | ) |  | (32,064 | ) |  | (24,992 | )
Net loss |  | (41,233 | ) |  | (38,914 | ) |  | (35,167 | ) |  | (26,796 | )
Basic and diluted net loss per common share(1) |  | $ | (1.22 | ) |  | $ | (1.14 | ) |  | $ | (1.03 | ) |  | $ | (0.78 | )
2015: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 5,069 |  |  | $ | 6,161 |  |  | $ | 9,772 |  |  | $ | 12,694 |
Collaboration and grant revenue |  | 2,413 |  |  | 613 |  |  | 4 |  |  | 40 |
Operating expenses |  | 45,553 |  |  | 45,400 |  |  | 52,008 |  |  | 60,935 |
Loss from operations |  | (38,071 | ) |  | (38,626 | ) |  | (42,232 | ) |  | (48,201 | )
Net loss |  | (37,915 | ) |  | (38,361 | ) |  | (43,223 | ) |  | (50,948 | )
Basic and diluted net loss per common share(1) |  | $ | (1.15 | ) |  | $ | (1.14 | ) |  | $ | (1.27 | ) |  | $ | (1.50 | )
(1) | The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.

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- Definition Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a)-(j) -URI http://asc.fasb.org/extlink&oid=68076893&loc=d3e1280-108306 + Details
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