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v3.6.0.2

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenues: |  |  |
Net product revenue | $ 81,447 | $ 33,696 | $ 717
Collaboration and grant revenue | 1,258 | 3,070 | 24,528
Total revenues | 82,705 | 36,766 | 25,245
Operating expenses: |  |  |
Research and development | 117,633 | 121,816 | 79,838
Selling, general and administrative | 97,130 | 82,080 | 44,820
Total operating expenses | 214,763 | 203,896 | 124,658
Loss from operations | (132,058) | (167,130) | (99,413)
Interest (expense) income, net | (8,276) | (2,367) | 1,180
Other expense, net | (1,207) | (465) | (213)
Loss from operations before tax (expense) benefit | (141,541) | (169,962) | (98,446)
Income tax (expense) benefit | (569) | (485) | 4,693
Net loss attributable to common stockholders | $ (142,110) | $ (170,447) | $ (93,753)
Weighted-average shares outstanding: |  |  |
Basic and diluted (in shares) | 34,044,584 | 33,626,248 | 31,565,310
Net loss per share—basic and diluted (in dollars per share) | $ (4.17) | $ (5.07) | $ (2.97)

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