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Income taxes (Details 4) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Deferred tax assets: |  |
Accrued Expense | $ 849 | $ 848
Amortization | 46 | 57
Depreciation | 2,968 | 2,631
Federal tax credits | 74,475 | 50,850
State tax credits | 4,996 | 3,356
Federal net operating losses | 80,061 | 75,200
State net operating losses | 9,672 | 8,848
Capitalized research and development costs | 7,248 | 8,917
Other | 22,125 | 10,345
Total gross deferred tax assets | 202,440 | 161,052
Less valuation allowance | (183,015) | (139,584)
Total deferred tax assets, net of valuation allowance | 19,425 | 21,468
Deferred tax liabilities: |  |
Convertible debt | (19,190) | (21,468)
Gain on marketable securities | (235) | 0
Total gross deferred tax assets | (19,425) | (21,468)
Net deferred tax assets (liabilities) | $ 0 | $ 0

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