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Stock award plan (Tables) | 12 Months Ended
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Dec. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Summary of stock option activity | A summary of stock option activity is as follows:
|  | Number of options |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value
|  |  |  |  |  |  |  | (in thousands)
Outstanding at December 31, 2013 |  | 2,095,592 |  |  | $ | 20.24 |  |  |  |  |  |
Granted |  | 1,639,996 |  |  | $ | 31.09 |  |  |  |  |  |
Exercised |  | (108,645 | ) |  | $ | 11.00 |  |  |  |  |  |
Forfeited |  | (193,971 | ) |  | $ | 32.91 |  |  |  |  |  |
Outstanding at December 31, 2014 |  | 3,432,972 |  |  | $ | 25.00 |  |  |  |  |  |
Granted |  | 2,201,800 |  |  | $ | 50.81 |  |  |  |  |  |
Exercised |  | (656,248 | ) |  | $ | 13.27 |  |  |  |  |  |
Forfeited |  | (152,047 | ) |  | $ | 49.58 |  |  |  |  |  |
Outstanding at December 31, 2015 |  | 4,826,477 |  |  | $ | 37.20 |  |  |  |  |  |
Granted |  | 1,500,645 |  |  | $ | 27.90 |  |  |  |  |  |
Exercised |  | (89,216 | ) |  | $ | 10.85 |  |  |  |  |  |
Forfeited |  | (383,590 | ) |  | $ | 47.42 |  |  |  |  |  |
Outstanding at December 31, 2016 |  | 5,854,316 |  |  | $ | 34.71 |  |  | 7.80 years |  | $ | 341 |
Vested or Expected to vest at December 31, 2016 |  | 2,792,870 |  |  | $ | 35.66 |  |  | 8.36 years |  | $ | 249 |
Exercisable at December 31, 2016 |  | 2,903,325 |  |  | $ | 33.73 |  |  | 7.22 years |  | $ | 72 |
Schedule of assumptions used to estimate fair values of grants made on the date of grant | The fair values of grants made in the years ended December 31, 2016, 2015 and 2014 were contemporaneously estimated on the date of grant using the following assumptions:
|  | 2016 |  | 2015 |  | 2014
Risk-free interest rate |  | 1.30 - 2.24% |  | 1.48 - 2.18% |  | 0.11 - 2.04%
Expected volatility |  | 67 - 78% |  | 67 - 69% |  | 70 - 91%
Expected term |  | 5.05 - 10.00 years |  | 5.50 - 9.12 years |  | 5.50 - 6.25 years
Summary of information on the Company's restricted stock | The following table summarizes information on the Company’s restricted stock awards and units:
|  | Restricted Stock Awards and Units
|  | Number of Shares |  | Weighted Average Grant Date Fair Value
Unvested at December 31, 2015 |  | 344,335 |  |  | $ | 10.85 |
Granted |  | 141,185 |  |  | $ | 30.86 |
Vested |  | (163,635 | ) |  | $ | 10.85 |
Forfeited |  | (50,234 | ) |  | $ | 18.93 |
Unvested at December 31, 2016 |  | 271,651 |  |  | $ | 19.76 |
Schedule of share-based compensation expense recorded in the statement of operations | The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:
|  | Year ended December 31,
|  | 2016 |  | 2015 |  | 2014
Research and development |  | $ | 16,812 |  |  | $ | 16,138 |  |  | $ | 9,739 |
Selling, general and administrative |  | 18,197 |  |  | 17,841 |  |  | 9,571 |
Total |  | $ | 35,009 |  |  | $ | 33,979 |  |  | $ | 19,310 |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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