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The Company (Details) $ in Thousands | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Aug. 31, 2014 state | Dec. 31, 2016 USD ($) country | Dec. 31, 2014 | Dec. 31, 2015 USD ($) | Aug. 31, 2015
Minimum age of ambulatory patient | 5 years |  | 5 years |  |
Number of States In European Economic Area | state | 31 |  |  |  |
Number of countries made availability of Translama on a commercial basis | country |  | 25 |  |  |
Accumulated deficit | $ |  | $ (735,108) |  | $ (592,998) |
3.00% Convertible senior notes due 2022 | Convertible debt |  |  |  |  |
Interest rate |  |  |  |  | 3.00%

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