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Income taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2016, 2015, and 2014:

		2016			2015			2014
Domestic		(61,446	)		(50,944	)		(46,501	)
Foreign		(80,095	)		(119,018	)		(51,945	)
Total		(141,541	)		(169,962	)		(98,446	)

Components of Income Tax Provision

The Income Tax Provision consisted of the following for the years ended December 31, 2016, 2015 and 2014:

		2016				2015				2014
Current:
U.S. Federal		$	—			$	—			$	—
U.S. State and Local		(2		)		(2		)		4,890
Foreign		(766		)		(483		)		(197		)
Deferred:
U.S. Federal		199				—				—
U.S. State and Local		—				—				—
Foreign		—				—				—
Total Tax (Expense) Benefit		$	(569	)		$	(485	)		$	4,693

Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate

A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:

		December 31,
		2016			2015			2014
Federal income tax (benefit) at statutory rate		34.00	%		34.00	%		34.00	%
State income tax benefit, net of federal benefit		3.05			(0.43	)		(1.60	)
Permanent differences		(3.70	)		(6.61	)		(0.93	)
NOL IRC Section 382 Limitations		—			—			(21.53	)
Research and development		16.66			19.50			3.78
Increase to valuation allowance		(30.72	)		(20.87	)		9.17
Foreign tax rate differential		(19.84	)		(24.06	)		(18.14	)
Benefit allocated from other comprehensive income		0.14			—			—
Other		0.01			(1.82	)		0.01
Effective income tax rate		(0.40	)%		(0.29	)%		4.76	%

Schedule of significant components of the Company's deferred tax assets and liabilities

The significant components of the Company’s deferred tax assets and liabilities at December 31, 2016 and 2015 are as follows:

		2016				2015
Deferred tax assets:
Accrued Expense		$	849			$	848
Amortization		46				57
Depreciation		2,968				2,631
Federal tax credits		74,475				50,850
State tax credits		4,996				3,356
Federal net operating losses		80,061				75,200
State net operating losses		9,672				8,848
Capitalized research and development costs		7,248				8,917
Other		22,125				10,345
Total gross deferred tax assets		202,440				161,052
Less valuation allowance		(183,015		)		(139,584		)
Total deferred tax assets, net of valuation allowance		$	19,425			$	21,468
Deferred tax liabilities:
Convertible debt		$	(19,190	)		$	(21,468	)
Gain on marketable securities		$	(235	)		$	—
Total gross deferred tax assets		(19,425		)		(21,468		)
Net deferred tax assets (liabilities)		$	—			$	—

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32639-109319

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32537-109319

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32687-109319

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(h)(1)(i))
-URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690

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