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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Net product revenue $ 81,447 $ 33,696 $ 717
Collaboration and grant revenue 1,258 3,070 24,528
Total revenues 82,705 36,766 25,245
Operating expenses:      
Research and development 117,633 121,816 79,838
Selling, general and administrative 97,130 82,080 44,820
Total operating expenses 214,763 203,896 124,658
Loss from operations (132,058) (167,130) (99,413)
Interest (expense) income, net (8,276) (2,367) 1,180
Other expense, net (1,207) (465) (213)
Loss from operations before tax (expense) benefit (141,541) (169,962) (98,446)
Income tax (expense) benefit (569) (485) 4,693
Net loss attributable to common stockholders $ (142,110) $ (170,447) $ (93,753)
Weighted-average shares outstanding:      
Basic and diluted (in shares) 34,044,584 33,626,248 31,565,310
Net loss per share—basic and diluted (in dollars per share) $ (4.17) $ (5.07) $ (2.97)