XML 54 R40.htm IDEA: XBRL DOCUMENT v3.6.0.2
Selected quarterly financial data (Tables)
 12 Months Ended
Dec. 31, 2016
Quarterly Financial Information Disclosure [Abstract]  
Summary of quarterly data
The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2016 and 2015 are as follows:
 
 
For the quarters ending
 
 
March 31
 
June 30
 
September 30
 
December 31
2016:
 
 

 
 

 
 

 
 

Net product revenue
 
$
18,878

 
$
15,437

 
$
22,013

 
$
25,119

Collaboration and grant revenue
 
17

 
196

 
973

 
72

Operating expenses
 
57,337

 
52,193

 
55,050

 
50,183

Loss from operations
 
(38,442
)
 
(36,560
)
 
(32,064
)
 
(24,992
)
Net loss
 
(41,233
)
 
(38,914
)
 
(35,167
)
 
(26,796
)
Basic and diluted net loss per common share(1)
 
$
(1.22
)
 
$
(1.14
)
 
$
(1.03
)
 
$
(0.78
)
2015:
 
 

 
 

 
 

 
 

Net product revenue
 
$
5,069

 
$
6,161

 
$
9,772

 
$
12,694

Collaboration and grant revenue
 
2,413

 
613

 
4

 
40

Operating expenses
 
45,553

 
45,400

 
52,008

 
60,935

Loss from operations
 
(38,071
)
 
(38,626
)
 
(42,232
)
 
(48,201
)
Net loss
 
(37,915
)
 
(38,361
)
 
(43,223
)
 
(50,948
)
Basic and diluted net loss per common share(1)
 
$
(1.15
)
 
$
(1.14
)
 
$
(1.27
)
 
$
(1.50
)
 
 
(1)
The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.