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The Company (Details) $ in Thousands	1 Months Ended	12 Months Ended
	Aug. 31, 2014 state	Dec. 31, 2016 USD ($) country	Dec. 31, 2014	Dec. 31, 2015 USD ($)	Aug. 31, 2015
Minimum age of ambulatory patient	5 years		5 years
Number of States In European Economic Area | state	31
Number of countries made availability of Translama on a commercial basis | country		25
Accumulated deficit | $		$ (735,108)		$ (592,998)
3.00% Convertible senior notes due 2022 | Convertible debt
Interest rate					3.00%

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Contractual interest rate for funds borrowed, under the debt agreement.

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