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Summary of significant accounting policies (Details) - 12 months ended Dec. 31, 2016
Total
item
segment
Segment and geographic information      
Number of operating segments   1 1
Computer equipment and software      
Fixed assets      
Estimated useful life 3 years    
Furniture, fixtures, and lab equipment | Minimum      
Fixed assets      
Estimated useful life 3 years    
Furniture, fixtures, and lab equipment | Maximum      
Fixed assets      
Estimated useful life 7 years