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Earnings per share (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Numerator                      
Net loss $ (26,796) $ (35,167) $ (38,914) $ (41,233) $ (50,948) $ (43,223) $ (38,361) $ (37,915) $ (142,110) $ (170,447) $ (93,753)
Denominator                      
Denominator for basic and diluted net loss per share (in shares)                 34,044,584 33,626,248 31,565,310
Net loss per share:                      
Basic and diluted (in dollars per share) $ (0.78) $ (1.03) $ (1.14) $ (1.22) $ (1.50) $ (1.27) $ (1.14) $ (1.15) $ (4.17) $ (5.07) $ (2.97)
Total shares excluded from calculation (in shares)                 6,125,967 5,170,812 4,151,372
Stock Options                      
Net loss per share:                      
Total shares excluded from calculation (in shares)                 5,854,316 4,826,477 3,432,972
Unvested restricted stock                      
Net loss per share:                      
Total shares excluded from calculation (in shares)                 271,651 344,335 718,400