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Collaborations and grants (Details)
1 Months Ended 12 Months Ended
Jan. 02, 2011
item
Nov. 30, 2014
USD ($)
Jan. 31, 2014
USD ($)
Nov. 30, 2011
USD ($)
item
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Minimum              
Grant revenue              
Term of grant program         2 years    
Maximum              
Grant revenue              
Term of grant program         5 years    
Collaboration agreement | Development event milestones              
Collaborations and grants              
Collaboration revenue recognized   $ 10,000,000 $ 7,500,000        
Collaboration agreement | Roche and SMA Foundation [Member]              
Collaborations and grants              
Number of compounds in preclinical development | item       3      
Deferred revenue       $ 30,000,000      
Number of significant deliverables | item       2      
Research period for applying technology       2 years      
Collaboration revenue recognized         $ 400,000 $ 600,000 $ 20,200,000
Collaboration agreement | Roche and SMA Foundation [Member] | Development event milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         135,000,000    
Collaboration agreement | Roche and SMA Foundation [Member] | Sales milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         325,000,000    
Early stage collaboration and discovery agreements              
Collaborations and grants              
Deferred revenue         $ 0 0 1,800,000
Number of significant deliverables | item 2            
Collaboration revenue recognized           $ 1,800,000 $ 1,300,000
Early stage collaboration and discovery agreements | Minimum              
Collaborations and grants              
Research period for applying technology         3 years    
Early stage collaboration and discovery agreements | Maximum              
Collaborations and grants              
Research period for applying technology         4 years    
Early stage collaboration and discovery agreements | Development event milestones              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         $ 143,000,000    
Early stage collaboration and discovery agreements | Sales milestones | Maximum              
Collaborations and grants              
Additional consideration receivable upon achievement of specified events         $ 252,000,000