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Income taxes (Details 3)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Reconciliation of the U.S. statutory income tax rate to the entity's effective tax rate      
Federal income tax (benefit) at statutory rate (as a percent) 34.00% 34.00% 34.00%
State income tax benefit, net of federal benefit (as a percent) 3.05% (0.43%) (1.60%)
Permanent differences (as a percent) (3.70%) (6.61%) (0.93%)
NOL IRC Section 382 Limitations (as a percent) 0.00% 0.00% (21.53%)
Research and development (as a percent) 16.66% 19.50% 3.78%
Increase to valuation allowance (as a percent) (30.72%) (20.87%) 9.17%
Foreign tax rate differential (as a percent) (19.84%) (24.06%) (18.14%)
Benefit allocated from other comprehensive income (as a percent) 0.14% 0.00% 0.00%
Other (as a percent) 0.01% (1.82%) 0.01%
Effective income tax rate (as a percent) (0.40%) (0.29%) 4.76%