XML 81 R67.htm IDEA: XBRL DOCUMENT v3.6.0.2
Income taxes (Details 5) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating loss carryforwards      
Valuation allowance $ 183,015 $ 139,584  
Valuation allowance, deferred tax asset, increase (decrease) (43,400) $ 16,300  
Orphan drug credit carryover 60,100    
Limited NOL carryforwards 231,500    
Operating loss carryforwards, not subject to expiration $ 169,200    
NOL carryforward period 20 years    
Operating loss carryforwards, subject to expiration $ 62,300    
Operating loss carryforwards for immediate use 175,100    
Operating loss carryforwards in next twelve months $ 16,700    
Federal income tax (benefit) at statutory rate (as a percent) 34.00% 34.00% 34.00%
Uncertain tax position $ 0    
First five years from ownership change      
Operating loss carryforwards      
Net operating loss carryforwards 16,700    
After five years      
Operating loss carryforwards      
Net operating loss carryforwards 5,700    
Federal      
Operating loss carryforwards      
Net operating loss carryforwards 285,800    
Operating loss carryforwards associated to exercise of stock options and vesting of restricted stock 50,400    
Tax benefit related to operating loss carryforwards 17,100    
Research and development credit carryforwards 14,400    
State      
Operating loss carryforwards      
Net operating loss carryforwards 213,200    
Research and development credit carryforwards $ 7,300