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Commitments and contingencies (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Jan. 31, 2017	Jun. 30, 2016
Other contingencies
Operating leases, rent expense	$ 2.2	$ 1.8	$ 0.9
Funding agreement | Wellcome trust limited
Other contingencies
Development and regulatory milestone payments which the entity may be obligated to pay					$ 0.8
Subsequent Event | Funding agreement | Maximum | Wellcome trust limited
Other contingencies
Development and regulatory milestone payments which the entity may be obligated to pay				$ 22.4

X

- Definition

Represents the development and regulatory milestones payments which the entity may be obligated to pay under certain contractual agreements.

+ References

No definition available.

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

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- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

+ Details

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- Definition

Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 840
-SubTopic 20
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6453985&loc=d3e41499-112717

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- Details

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- Details

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