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Subsequent events (Details) - USD ($) | May 05, 2017 | Apr. 20, 2017
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Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC | Subsequent Event |  |
Subsequent Event [Line Items] |  |
Consideration transferred |  | $ 140,000,000
Payments to acquire businesses |  | $ 75,000,000
Equity Interest Issued, number of shares (in shares) |  | 6,683,598
Scenario, Forecast | Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC |  |
Subsequent Event [Line Items] |  |
Development and regulatory milestone payments which the entity may be obligated to pay |  | $ 50,000,000
MidCap Financial Trust | Term Loan Facility | Subsequent Event |  |
Subsequent Event [Line Items] |  |
Line of credit facility, maximum borrowing capacity | $ 60,000,000 |
Proceeds from lines of credit | 40,000,000 |
Line of credit facility, additional capacity available, net product revenue threshold | 20,000,000 |
Line of credit facility, net product revenue threshold, additional capacity | 120,000,000 |
Line of credit facility, net product revenue threshold | $ 100,000,000 |
London Interbank Offered Rate (LIBOR) | MidCap Financial Trust | Term Loan Facility | Subsequent Event |  |
Subsequent Event [Line Items] |  |
Debt instrument, floor interest rate | 1.00% |
Debt instrument, basis spread on variable rate | 6.15% |

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