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The Company (Details) $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Apr. 20, 2017 USD ($) shares | Aug. 31, 2014 state | Dec. 31, 2016 USD ($) country | Mar. 31, 2017 USD ($) | Aug. 31, 2015
Long-term debt |  |  |  |  |
Minimum age of ambulatory patient |  | 5 years |  |  |
Number of member states of the European Economic Area | state |  | 31 |  |  |
Number of countries | country |  |  | 25 |  |
Accumulated deficit |  |  | $ (735,108) | $ (764,165) |
Convertible debt | 3.00% Convertible senior notes due 2022 |  |  |  |  |
Long-term debt |  |  |  |  |
Interest rate |  |  |  |  | 3.00%
Non-collaborative Arrangement Transactions | Subsequent Event | Marathon Pharmaceuticals, LLC |  |  |  |  |
Long-term debt |  |  |  |  |
Consideration transferred | $ 140,000 |  |  |  |
Payments to acquire businesses | 75,000 |  |  |  |
Equity interest issued or issuable, value assigned | $ 65,000 |  |  |  |
Equity Interest Issued, number of shares (in shares) | shares | 6,683,598 |  |  |  |
Trading day period | 15 days |  |  |  |
Scenario, Forecast | Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC |  |  |  |  |
Long-term debt |  |  |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay | $ 50,000 |  |  |  |

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