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Stock award plan (Tables) | 3 Months Ended
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Mar. 31, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Summary of stock option activity | A summary of stock option activity is as follows:
|  | Number of options |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value
|  |  |  |  |  |  |  | (in thousands)
Outstanding at December 31, 2016 |  | 5,854,316 |  |  | $ | 34.71 |  |  |  |  |  |
Granted |  | 1,244,723 |  |  | $ | 11.32 |  |  |  |  |  |
Exercised |  | (9,766 | ) |  | $ | 10.85 |  |  |  |  |  |
Forfeited/Cancelled |  | (81,983 | ) |  | $ | 35.64 |  |  |  |  |  |
Outstanding at March 31, 2017 |  | 7,007,290 |  |  | $ | 30.56 |  |  | 7.87 years |  | $ | 179 |
Vested or Expected to vest at March 31, 2017 |  | 3,296,281 |  |  | $ | 28.16 |  |  | 8.68 years |  | $ | 144 |
Exercisable at March 31, 2017 |  | 3,478,720 |  |  | $ | 33.28 |  |  | 7.03 years |  | $ | 25 |
Schedule of assumptions used to estimate fair values of grants made on the date of grant | The fair value of grants made in the three months ended March 31, 2017 was contemporaneously estimated on the date of grant using the following assumptions:
|  | Three months ended March 31, 2017 |
Risk-free interest rate |  | 1.94% — 2.45% |
Expected volatility |  | 76%—81% |
Expected term |  | 5.04– 10.00 years |
Summary of information on the Company's restricted stock | The following table summarizes information on the Company’s restricted stock awards and units:
|  | Restricted Stock Awards and Units
|  | Number of Shares |  | Weighted Average Grant Date Fair Value
January 1, 2017 |  | 271,651 |  |  | $ | 19.76 |
Granted |  | 328,194 |  |  | $ | 11.23 |
Vested |  | (30,161 | ) |  | $ | 30.86 |
Forfeited |  | (3,090 | ) |  | $ | 13.98 |
Unvested at March 31, 2017 |  | 566,594 |  |  | $ | 14.26 |
Schedule of share-based compensation expense recorded in the statement of operations | The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:
|  | Three Months Ended March 31,
|  | 2017 |  | 2016
Research and development |  | $ | 4,467 |  |  | $ | 4,328 |
Selling, general and administrative |  | 4,562 |  |  | 4,587 |
Total |  | $ | 9,029 |  |  | $ | 8,915 |

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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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