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Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Revenues: |  |
Net product revenue | $ 26,442 | $ 18,878
Collaboration and grant revenue | 105 | 17
Total revenues | 26,547 | 18,895
Operating expenses: |  |
Cost of product sales | 39 | 0
Research and development | 27,363 | 31,399
Selling, general and administrative | 25,500 | 25,938
Total operating expenses | 52,902 | 57,337
Loss from operations | (26,355) | (38,442)
Interest expense, net | (2,219) | (1,956)
Other expense, net | (318) | (721)
Loss before income tax expense | (28,892) | (41,119)
Income tax expense | (165) | (114)
Net loss attributable to common stockholders | $ (29,057) | $ (41,233)
Weighted-average shares outstanding: |  |
Basic and diluted (in shares) | 34,305,948 | 33,919,169
Net loss per share-basic and diluted (in dollars per share) |  |
Net loss per share—basic and diluted (in dollars per share) | $ (0.85) | $ (1.22)

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