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The Company (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Apr. 20, 2017
USD ($)
shares
Aug. 31, 2014
state
Dec. 31, 2016
USD ($)
country
Mar. 31, 2017
USD ($)
Aug. 31, 2015
Long-term debt          
Minimum age of ambulatory patient   5 years      
Number of member states of the European Economic Area | state   31      
Number of countries | country     25    
Accumulated deficit     $ (735,108) $ (764,165)  
Convertible debt | 3.00% Convertible senior notes due 2022          
Long-term debt          
Interest rate         3.00%
Non-collaborative Arrangement Transactions | Subsequent Event | Marathon Pharmaceuticals, LLC          
Long-term debt          
Consideration transferred $ 140,000        
Payments to acquire businesses 75,000        
Equity interest issued or issuable, value assigned $ 65,000        
Equity Interest Issued, number of shares (in shares) | shares 6,683,598        
Trading day period 15 days        
Scenario, Forecast | Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC          
Long-term debt          
Development and regulatory milestone payments which the entity may be obligated to pay $ 50,000