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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Revenues:    
Net product revenue $ 26,442 $ 18,878
Collaboration and grant revenue 105 17
Total revenues 26,547 18,895
Operating expenses:    
Cost of product sales 39 0
Research and development 27,363 31,399
Selling, general and administrative 25,500 25,938
Total operating expenses 52,902 57,337
Loss from operations (26,355) (38,442)
Interest expense, net (2,219) (1,956)
Other expense, net (318) (721)
Loss before income tax expense (28,892) (41,119)
Income tax expense (165) (114)
Net loss attributable to common stockholders $ (29,057) $ (41,233)
Weighted-average shares outstanding:    
Basic and diluted (in shares) 34,305,948 33,919,169
Net loss per share-basic and diluted (in dollars per share)    
Net loss per share—basic and diluted (in dollars per share) $ (0.85) $ (1.22)