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Subsequent events (Details) - USD ($)	May 05, 2017	Apr. 20, 2017
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC | Subsequent Event
Subsequent Event [Line Items]
Consideration transferred		$ 140,000,000
Payments to acquire businesses		$ 75,000,000
Equity Interest Issued, number of shares (in shares)		6,683,598
Scenario, Forecast | Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Subsequent Event [Line Items]
Development and regulatory milestone payments which the entity may be obligated to pay		$ 50,000,000
MidCap Financial Trust | Term Loan Facility | Subsequent Event
Subsequent Event [Line Items]
Line of credit facility, maximum borrowing capacity	$ 60,000,000
Proceeds from lines of credit	40,000,000
Line of credit facility, additional capacity available, net product revenue threshold	20,000,000
Line of credit facility, net product revenue threshold, additional capacity	120,000,000
Line of credit facility, net product revenue threshold	$ 100,000,000
London Interbank Offered Rate (LIBOR) | MidCap Financial Trust | Term Loan Facility | Subsequent Event
Subsequent Event [Line Items]
Debt instrument, floor interest rate	1.00%
Debt instrument, basis spread on variable rate	6.15%

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