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The Company (Details) $ in Thousands |  |  | 1 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jun. 30, 2017 USD ($) number_country | Apr. 20, 2017 USD ($) shares | Aug. 31, 2014 member_state | Dec. 31, 2016 USD ($) | Aug. 31, 2015
Long-term debt |  |  |  |  |
Minimum age of ambulatory patient |  |  | 5 years |  |
Number of member states of the European Economic Area | member_state |  |  | 31 |  |
Number of countries | number_country | 25 |  |  |  |
Retained earnings (Accumulated deficit) | $ (781,640) |  |  | $ (735,108) |
Convertible debt | 3.00% Convertible senior notes due 2022 |  |  |  |  |
Long-term debt |  |  |  |  |
Interest rate |  |  |  |  | 3.00%
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC |  |  |  |  |
Long-term debt |  |  |  |  |
Cash consideration (upfront payment to Marathon) |  | $ 75,000 |  |  |
Equity Interest Issued, number of shares (in shares) | shares |  | 6,683,598 |  |  |
Numerator for calculation of number of shares of equity interests issued to acquire entity |  | $ 65,000 |  |  |
Trading day period |  | 15 days |  |  |
Development and regulatory milestone payments which the entity may be obligated to pay |  | $ 50,000 |  |  |

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