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Stock award plan (Tables) | 6 Months Ended
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Jun. 30, 2017
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] |
Summary of stock option activity | A summary of stock option activity is as follows:
|  | Number of options |  | Weighted- average exercise price |  | Weighted- average remaining contractual term |  | Aggregate intrinsic value
|  |  |  |  |  |  |  | (in thousands)
Outstanding at December 31, 2016 |  | 5,854,316 |  |  | $ | 34.71 |  |  |  |  |  |
Granted |  | 1,738,873 |  |  | $ | 11.80 |  |  |  |  |  |
Exercised |  | (49,770 | ) |  | $ | 10.74 |  |  |  |  |  |
Forfeited/Cancelled |  | (419,367 | ) |  | $ | 33.83 |  |  |  |  |  |
Outstanding at June 30, 2017 |  | 7,124,052 |  |  | $ | 29.33 |  |  | 7.51 years |  | $ | 19,807 |
Vested or Expected to vest at June 30, 2017 |  | 3,159,956 |  |  | $ | 25.63 |  |  | 8.66 years |  | $ | 10,427 |
Exercisable at June 30, 2017 |  | 3,738,673 |  |  | $ | 32.94 |  |  | 6.44 years |  | $ | 8,449 |
Schedule of assumptions used to estimate fair values of grants made on the date of grant | The fair value of grants made in the six months ended June 30, 2017 was contemporaneously estimated on the date of grant using the following assumptions:
|  | Six months ended June 30, 2017 |
Risk-free interest rate |  | 1.84% — 2.45% |
Expected volatility |  | 76%—81% |
Expected term |  | 5.04– 10.00 years |
Summary of information on the Company's restricted stock | The following table summarizes information on the Company’s restricted stock awards and units:
|  | Restricted Stock Awards and Units
|  | Number of Shares |  | Weighted Average Grant Date Fair Value
January 1, 2017 |  | 271,651 |  |  | $ | 19.76 |
Granted |  | 358,194 |  |  | $ | 11.34 |
Vested |  | (180,861 | ) |  | $ | 14.19 |
Forfeited |  | (24,998 | ) |  | $ | 13.47 |
Unvested at June 30, 2017 |  | 423,986 |  |  | $ | 15.39 |
Schedule of share-based compensation expense recorded in the statement of operations | The Company recorded share-based compensation expense in the statement of operations related to incentive stock options, nonstatutory stock options, restricted stock awards, restricted stock units and the ESPP as follows:
|  | Three Months Ended June 30, |  | Six Months Ended June 30,
|  | 2017 |  | 2016 |  | 2017 |  | 2016
Research and development |  | $ | 3,895 |  |  | $ | 4,087 |  |  | $ | 8,362 |  |  | $ | 8,415 |
Selling, general and administrative |  | 3,990 |  |  | 4,649 |  |  | 8,552 |  |  | 9,236 |
Total |  | $ | 7,885 |  |  | $ | 8,736 |  |  | $ | 16,914 |  |  | $ | 17,651 |

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- Definition Tabular disclosure of the changes in outstanding nonvested restricted stock shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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