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Accounts payable and accrued expenses (Details) - USD ($) $ in Thousands | Jun. 30, 2017 | Dec. 31, 2016
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Payables and Accruals [Abstract] |  |
Employee compensation, benefits, and related accruals | $ 11,064 | $ 13,649
Consulting and contracted research | 11,006 | 11,505
Professional fees | 2,252 | 1,237
Sales allowance and other costs | 23,836 | 13,245
Accounts payable | 6,062 | 6,298
Other | 9,776 | 2,825
Accounts payable and accrued expenses | $ 63,996 | $ 48,759

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