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Consolidated Statements of Operations (unaudited) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Revenues:        
Net product revenue $ 47,891 $ 15,437 $ 74,334 $ 34,314
Collaboration and grant revenue 71 196 176 214
Total revenues 47,962 15,633 74,510 34,528
Operating expenses:        
Cost of product sales 758 0 797 0
Research and development 30,835 28,827 58,198 60,226
Selling, general and administrative 28,866 23,366 54,365 49,304
Total operating expenses 60,459 52,193 113,360 109,530
Loss from operations (12,497) (36,560) (38,850) (75,002)
Interest expense, net (3,008) (2,060) (5,227) (4,016)
Other expense, net (1,820) (387) (2,139) (1,107)
Loss before income tax expense (17,325) (39,007) (46,216) (80,125)
Income tax (expense) benefit (150) 93 (316) (22)
Net loss attributable to common stockholders $ (17,475) $ (38,914) $ (46,532) $ (80,147)
Weighted-average shares outstanding:        
Basic and diluted (in shares) 39,621,738 34,000,333 36,978,528 33,959,751
Net loss per share-basic and diluted (in dollars per share)        
Net loss per share—basic and diluted (in dollars per share) $ (0.44) $ (1.14) $ (1.26) $ (2.36)