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Income taxes - Narrative (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating loss carryforwards |  |  |
Valuation allowance | $ 177,631 | $ 183,015 |
Valuation allowance, deferred tax asset, increase (decrease) | 5,400 | $ 43,400 |
Orphan drug credit carryover | 67,800 |  |
Limited NOL carryforwards | 231,500 |  |
Operating loss carryforwards, not subject to expiration | 169,200 |  |
Operating loss carryforwards, subject to expiration | 62,300 |  |
Operating loss carryforwards for immediate use | 196,700 |  |
Operating loss carryforwards in next twelve months | $ 11,200 |  |
Federal income tax at statutory rate | 34.00% | 34.00% | 34.00%
Uncertain tax position | $ 0 |  |
Change In tax rate, deferred tax asset, provisional income tax expense | 46,100 |  |
First five years from ownership change |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 16,700 |  |
After five years |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 5,700 |  |
Federal |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 290,800 |  |
Research and development credit carryforwards | 13,200 |  |
State |  |  |
Operating loss carryforwards |  |  |
Net operating loss carryforwards | 167,100 |  |
Research and development credit carryforwards | 8,700 |  |
Accounting Standards Update 2016-09 |  |  |
Operating loss carryforwards |  |  |
Share-based compensation cost | $ 50,400 |  |

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