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Selected quarterly financial data (Unaudited) | 12 Months Ended
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Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract] |
Selected quarterly financial data (Unaudited) | Selected quarterly financial data (Unaudited) The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2017 and 2016 are as follows:
|  | For the quarters ending
|  | March 31 |  | June 30 |  | September 30 |  | December 31
2017: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 26,442 |  |  | $ | 47,891 |  |  | $ | 41,780 |  |  | $ | 57,953 |
Collaboration and grant revenue |  | 105 |  |  | 71 |  |  | 73 |  |  | 20,077 |
Operating expenses |  | 52,902 |  |  | 60,459 |  |  | 72,745 |  |  | 72,578 |
(Loss) income from operations |  | (26,355 | ) |  | (12,497 | ) |  | (30,892 | ) |  | 5,452 |
Net (loss) income |  | (29,057 | ) |  | (17,475 | ) |  | (33,738 | ) |  | 1,270 |
Basic and diluted net (loss) income per common share(1)(2) |  | $ | (0.85 | ) |  | $ | (0.44 | ) |  | $ | (0.82 | ) |  | $ | 0.03 |
2016: |  |  |  |  |  |  |  |  |  |  |  |
Net product revenue |  | $ | 18,878 |  |  | $ | 15,437 |  |  | $ | 22,013 |  |  | $ | 25,119 |
Collaboration and grant revenue |  | 17 |  |  | 196 |  |  | 973 |  |  | 72 |
Operating expenses |  | 57,337 |  |  | 52,193 |  |  | 55,050 |  |  | 50,183 |
Loss from operations |  | (38,442 | ) |  | (36,560 | ) |  | (32,064 | ) |  | (24,992 | )
Net loss |  | (41,233 | ) |  | (38,914 | ) |  | (35,167 | ) |  | (26,796 | )
Basic and diluted net loss per common share(1) |  | $ | (1.22 | ) |  | $ | (1.14 | ) |  | $ | (1.03 | ) |  | $ | (0.78 | )
(1) | The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.
(2) | Diluted net income per common share for the quarter ending December 31, 2017 excludes the conversion of the Convertible Notes as the effect of their inclusion is anti-dilutive during the period.

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- References No definition available. + Details
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- Definition The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -URI http://asc.fasb.org/topic&trid=2126967 + Details
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