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Income taxes (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Tax Disclosure [Abstract] |
Schedule of Income before Income Tax, Domestic and Foreign | The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2017, 2016, and 2015:
|  | 2017 |  | 2016 |  | 2015
Domestic |  | (54,588 | ) |  | (61,446 | ) |  | (50,944 | )
Foreign |  | (23,077 | ) |  | (80,095 | ) |  | (119,018 | )
Total |  | (77,665 | ) |  | (141,541 | ) |  | (169,962 | )
Components of Income Tax Provision | The Income Tax Provision consisted of the following for the years ended December 31, 2017, 2016 and 2015:
|  | 2017 |  | 2016 |  | 2015
Current: |  |  |  |  |  |  |  |
U.S. Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
U.S. State and Local |  | (6 | ) |  | (2 | ) |  | (2 | )
Foreign |  | (1,131 | ) |  | (766 | ) |  | (483 | )
Deferred: |  |  |  |  |  |
U.S. Federal |  | (198 | ) |  | 199 |  |  | — |
U.S. State and Local |  | — |  |  | — |  |  | — |
Foreign |  | — |  |  | — |  |  | — |
Total tax expense |  | $ | (1,335 | ) |  | $ | (569 | ) |  | $ | (485 | )
Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate | A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:
|  | December 31,
|  | 2017 |  | 2016 |  | 2015
Federal income tax at statutory rate |  | 34.00 | % |  | 34.00 | % |  | 34.00 | %
State income tax (benefit), net of federal benefit |  | (1.01 | ) |  | 3.05 |  |  | (0.43 | )
Permanent differences |  | (8.48 | ) |  | (3.70 | ) |  | (6.61 | )
Research and development |  | 19.53 |  |  | 16.66 |  |  | 19.50 |
(Increase) decrease to valuation allowance |  | 29.10 |  |  | (30.72 | ) |  | (20.87 | )
Change in deferred tax assets |  | (64.12 | ) |  | — |  |  | — |
Foreign tax rate differential |  | (10.33 | ) |  | (19.84 | ) |  | (24.06 | )
Benefit (expense) allocated from other comprehensive income |  | (0.26 | ) |  | 0.14 |  |  | — |
Other |  | (0.15 | ) |  | 0.01 |  |  | (1.82 | )
Effective income tax rate |  | (1.72 | )% |  | (0.40 | )% |  | (0.29 | )%
Schedule of significant components of the Company's deferred tax assets and liabilities | The significant components of the Company’s deferred tax assets and liabilities at December 31, 2017 and 2016 are as follows:
|  | 2017 |  | 2016
Deferred tax assets: |  |  |  |  |  |
Accrued Expense |  | $ | 625 |  |  | $ | 849 |
Amortization |  | 2,116 |  |  | 46 |
Depreciation |  | 1,749 |  |  | 2,968 |
Federal tax credits |  | 80,961 |  |  | 74,475 |
State tax credits |  | 7,148 |  |  | 4,996 |
Federal net operating losses |  | 61,068 |  |  | 80,061 |
State net operating losses |  | 11,884 |  |  | 9,672 |
Capitalized research and development costs |  | 3,332 |  |  | 7,248 |
Other |  | 18,815 |  |  | 22,125 |
Total gross deferred tax assets |  | 187,698 |  |  | 202,440 |
Less valuation allowance |  | (177,631 | ) |  | (183,015 | )
Total deferred tax assets, net of valuation allowance |  | $ | 10,067 |  |  | $ | 19,425 |
Deferred tax liabilities: |  |  |  |  |  |
Convertible debt |  | $ | (9,927 | ) |  | $ | (19,190 | )
OCI unrealized gains |  | $ | (140 | ) |  | $ | (235 | )
Total gross deferred tax assets |  | (10,067 | ) |  | (19,425 | )
Net deferred tax assets (liabilities) |  | $ | — |  |  | $ | — |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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