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v3.8.0.1

Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common stock | Additional paid-in capital | Accumulated other comprehensive (loss) income | Accumulated deficit
--- | --- | --- | --- | --- | ---
Balance at the beginning of the period at Dec. 31, 2014 | $ 298,467 | $ 33 | $ 721,722 | $ (737) | $ (422,551)
Balance (in shares) at Dec. 31, 2014 |  | 32,898,392 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Equity component of the convertible notes issuance, net | 55,754 |  | 55,754 |  |
Exercise of options | 8,711 | $ 1 | 8,710 |  |
Exercise of options (in shares) |  | 656,248 |  |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Restricted stock vesting and issuance (in shares) |  | 361,919 |  |  |
Share-based compensation expense | 33,979 |  | 33,979 |  |
Net loss | (170,447) |  |  |  | (170,447)
Comprehensive loss | (463) |  |  | (463) |
Balance at the end of the period at Dec. 31, 2015 | 226,001 | $ 34 | 820,165 | (1,200) | (592,998)
Balance (in shares) at Dec. 31, 2015 |  | 33,916,559 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Exercise of options | 968 | $ 0 | 968 |  |
Exercise of options (in shares) |  | 89,216 |  |  |
Restricted stock vesting and issuance | 0 |  |  |  |
Restricted stock vesting and issuance (in shares) |  | 163,635 |  |  |
Share-based compensation expense | 35,009 |  | 35,009 |  |
Net loss | (142,110) |  |  |  | (142,110)
Comprehensive loss | (285) |  |  | (285) |
Balance at the end of the period at Dec. 31, 2016 | 119,583 | $ 34 | 856,142 | (1,485) | (735,108)
Balance (in shares) at Dec. 31, 2016 |  | 34,169,410 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock related to acquisition | 75,191 | $ 7 | 75,184 |  |
Issuance of common stock related to acquisition (in shares) |  | 6,683,598 |  |  |
Exercise of options | 2,182 | $ 0 | 2,182 |  |
Exercise of options (in shares) |  | 202,085 |  |  |
Restricted stock vesting and issuance | 1 | $ 1 |  |  |
Restricted stock vesting and issuance (in shares) |  | 287,531 |  |  |
Issuance of common stock in connection with an employee stock purchase plan | 2,467 | $ 0 | 2,467 |  |
Issuance of common stock in connection with an employee stock purchase plan (in shares) |  | 269,771 |  |  |
Share-based compensation expense | 30,559 |  | 30,559 |  |
Net loss | (79,000) |  |  |  | (79,000)
Comprehensive loss | 5,454 |  |  | 5,454 |
Balance at the end of the period at Dec. 31, 2017 | $ 156,437 | $ 42 | $ 966,534 | $ 3,969 | $ (814,108)
Balance (in shares) at Dec. 31, 2017 |  | 41,612,395 |  |  |

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