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v3.8.0.1

Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues: |  |  |
Net product revenue | $ 174,066 | $ 81,447 | $ 33,696
Collaboration and grant revenue | 20,326 | 1,258 | 3,070
Total revenues | 194,392 | 82,705 | 36,766
Operating expenses: |  |  |
Cost of product sales, excluding amortization of acquired intangible asset | 4,577 | 0 | 0
Amortization of acquired intangible asset | 15,380 | 0 | 0
Research and development | 117,456 | 117,633 | 121,816
Selling, general and administrative | 121,271 | 97,130 | 82,080
Total operating expenses | 258,684 | 214,763 | 203,896
Loss from operations | (64,292) | (132,058) | (167,130)
Interest expense, net | (12,094) | (8,276) | (2,367)
Other expense, net | (1,279) | (1,207) | (465)
Loss before income tax expense | (77,665) | (141,541) | (169,962)
Income tax expense | (1,335) | (569) | (485)
Net loss attributable to common stockholders | $ (79,000) | $ (142,110) | $ (170,447)
Weighted-average shares outstanding: |  |  |
Basic and diluted (in shares) | 39,183,073 | 34,044,584 | 33,626,248
Net loss per share—basic and diluted (in dollars per share) | $ (2.02) | $ (4.17) | $ (5.07)

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