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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |
Net product revenue | $ 57,953 | $ 41,780 | $ 47,891 | $ 26,442 | $ 25,119 | $ 22,013 | $ 15,437 | $ 18,878 | $ 174,066 | $ 81,447 | $ 33,696
Collaboration and grant revenue | 20,077 | 73 | 71 | 105 | 72 | 973 | 196 | 17 | 20,326 | 1,258 | 3,070
Operating expenses | 72,578 | 72,745 | 60,459 | 52,902 | 50,183 | 55,050 | 52,193 | 57,337 | 258,684 | 214,763 | 203,896
Loss from operations | 5,452 | (30,892) | (12,497) | (26,355) | (24,992) | (32,064) | (36,560) | (38,442) | (64,292) | (132,058) | (167,130)
Net loss attributable to common stockholders | $ 1,270 | $ (33,738) | $ (17,475) | $ (29,057) | $ (26,796) | $ (35,167) | $ (38,914) | $ (41,233) | $ (79,000) | $ (142,110) | $ (170,447)
Net loss per share—basic and diluted (in dollars per share) | $ 0.03 | $ (0.82) | $ (0.44) | $ (0.85) | $ (0.78) | $ (1.03) | $ (1.14) | $ (1.22) | $ (2.02) | $ (4.17) | $ (5.07)

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