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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Deferred tax assets: |  |
Accrued Expense | $ 625 | $ 849
Amortization | 2,116 | 46
Depreciation | 1,749 | 2,968
Federal tax credits | 80,961 | 74,475
State tax credits | 7,148 | 4,996
Federal net operating losses | 61,068 | 80,061
State net operating losses | 11,884 | 9,672
Capitalized research and development costs | 3,332 | 7,248
Other | 18,815 | 22,125
Total gross deferred tax assets | 187,698 | 202,440
Less valuation allowance | (177,631) | (183,015)
Total deferred tax assets, net of valuation allowance | 10,067 | 19,425
Deferred tax liabilities: |  |
Convertible debt | (9,927) | (19,190)
OCI unrealized gains | (140) | (235)
Total gross deferred tax assets | (10,067) | (19,425)
Net deferred tax assets (liabilities) | $ 0 | $ 0

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