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Income taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

The loss from operations before tax (expense) benefit consisted of the following for the years ended December 31, 2017, 2016, and 2015:

		2017			2016			2015
Domestic		(54,588	)		(61,446	)		(50,944	)
Foreign		(23,077	)		(80,095	)		(119,018	)
Total		(77,665	)		(141,541	)		(169,962	)

Components of Income Tax Provision

The Income Tax Provision consisted of the following for the years ended December 31, 2017, 2016 and 2015:

		2017				2016				2015
Current:
U.S. Federal		$	—			$	—			$	—
U.S. State and Local		(6		)		(2		)		(2		)
Foreign		(1,131		)		(766		)		(483		)
Deferred:
U.S. Federal		(198		)		199				—
U.S. State and Local		—				—				—
Foreign		—				—				—
Total tax expense		$	(1,335	)		$	(569	)		$	(485	)

Schedule of reconciliation of the U.S. statutory income tax rate to the Company's effective tax rate

A reconciliation of the U.S. statutory income tax rate to the Company’s effective tax rate is as follows:

		December 31,
		2017			2016			2015
Federal income tax at statutory rate		34.00	%		34.00	%		34.00	%
State income tax (benefit), net of federal benefit		(1.01	)		3.05			(0.43	)
Permanent differences		(8.48	)		(3.70	)		(6.61	)
Research and development		19.53			16.66			19.50
(Increase) decrease to valuation allowance		29.10			(30.72	)		(20.87	)
Change in deferred tax assets		(64.12	)		—			—
Foreign tax rate differential		(10.33	)		(19.84	)		(24.06	)
Benefit (expense) allocated from other comprehensive income		(0.26	)		0.14			—
Other		(0.15	)		0.01			(1.82	)
Effective income tax rate		(1.72	)%		(0.40	)%		(0.29	)%

Schedule of significant components of the Company's deferred tax assets and liabilities

The significant components of the Company’s deferred tax assets and liabilities at December 31, 2017 and 2016 are as follows:

		2017				2016
Deferred tax assets:
Accrued Expense		$	625			$	849
Amortization		2,116				46
Depreciation		1,749				2,968
Federal tax credits		80,961				74,475
State tax credits		7,148				4,996
Federal net operating losses		61,068				80,061
State net operating losses		11,884				9,672
Capitalized research and development costs		3,332				7,248
Other		18,815				22,125
Total gross deferred tax assets		187,698				202,440
Less valuation allowance		(177,631		)		(183,015		)
Total deferred tax assets, net of valuation allowance		$	10,067			$	19,425
Deferred tax liabilities:
Convertible debt		$	(9,927	)		$	(19,190	)
OCI unrealized gains		$	(140	)		$	(235	)
Total gross deferred tax assets		(10,067		)		(19,425		)
Net deferred tax assets (liabilities)		$	—			$	—

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(h)(1)(i))
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