XML 16 R4.htm IDEA: XBRL DOCUMENT v3.8.0.1
Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenues:      
Net product revenue $ 174,066 $ 81,447 $ 33,696
Collaboration and grant revenue 20,326 1,258 3,070
Total revenues 194,392 82,705 36,766
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible asset 4,577 0 0
Amortization of acquired intangible asset 15,380 0 0
Research and development 117,456 117,633 121,816
Selling, general and administrative 121,271 97,130 82,080
Total operating expenses 258,684 214,763 203,896
Loss from operations (64,292) (132,058) (167,130)
Interest expense, net (12,094) (8,276) (2,367)
Other expense, net (1,279) (1,207) (465)
Loss before income tax expense (77,665) (141,541) (169,962)
Income tax expense (1,335) (569) (485)
Net loss attributable to common stockholders $ (79,000) $ (142,110) $ (170,447)
Weighted-average shares outstanding:      
Basic and diluted (in shares) 39,183,073 34,044,584 33,626,248
Net loss per share—basic and diluted (in dollars per share) $ (2.02) $ (4.17) $ (5.07)