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The Company (Details) $ in Thousands		1 Months Ended	12 Months Ended
	Apr. 20, 2017 USD ($) shares	Aug. 31, 2014	Dec. 31, 2017 USD ($) country	Dec. 31, 2016 USD ($)	Aug. 31, 2015
Minimum age of ambulatory patient		5 years
Accumulated deficit			$ (814,108)	$ (735,108)
3.00% Convertible senior notes due 2022 | Convertible debt
Interest rate					3.00%
Marathon Pharmaceuticals, LLC | Arrangement
Cash consideration	$ 75,000
Equity interest issued or issuable, number of shares (in shares) | shares	6,683,598
Numerator for calculation of number of shares of equity interests issued to acquire entity	$ 65,000
Trading day period	15 days
Development and regulatory milestone payments which the entity may be obligated to pay	$ 50,000
Translarna
Number of countries made availability of Translama on a commercial basis | country			25

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