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Fixed assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Fixed assets
Gross fixed assets	$ 41,220	$ 38,356
Less accumulated depreciation and amortization	(32,844)	(30,927)
Net fixed assets	8,376	7,429
Depreciation expense	2,300	3,300	$ 2,900
Leasehold improvements
Fixed assets
Gross fixed assets	14,078	14,038
Computer equipment and software
Fixed assets
Gross fixed assets	5,471	4,622
Furniture, fixtures, and lab equipment
Fixed assets
Gross fixed assets	20,776	19,343
Assets in process
Fixed assets
Gross fixed assets	$ 895	$ 353

X

- Definition

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
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-SubTopic 10
-Section 50
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- Definition

The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

+ References

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+ References

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+ References

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