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Selected quarterly financial data (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]
Net product revenue	$ 57,953	$ 41,780	$ 47,891	$ 26,442	$ 25,119	$ 22,013	$ 15,437	$ 18,878	$ 174,066	$ 81,447	$ 33,696
Collaboration and grant revenue	20,077	73	71	105	72	973	196	17	20,326	1,258	3,070
Operating expenses	72,578	72,745	60,459	52,902	50,183	55,050	52,193	57,337	258,684	214,763	203,896
Loss from operations	5,452	(30,892)	(12,497)	(26,355)	(24,992)	(32,064)	(36,560)	(38,442)	(64,292)	(132,058)	(167,130)
Net loss attributable to common stockholders	$ 1,270	$ (33,738)	$ (17,475)	$ (29,057)	$ (26,796)	$ (35,167)	$ (38,914)	$ (41,233)	$ (79,000)	$ (142,110)	$ (170,447)
Net loss per share—basic and diluted (in dollars per share)	$ 0.03	$ (0.82)	$ (0.44)	$ (0.85)	$ (0.78)	$ (1.03)	$ (1.14)	$ (1.22)	$ (2.02)	$ (4.17)	$ (5.07)

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- Definition

Amount of revenue earned from collaborative research and development and licensing agreements and non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements.

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The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 28
-URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 942
-SubTopic 225
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(22))
-URI http://asc.fasb.org/extlink&oid=6879574&loc=d3e536633-122882

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 944
-SubTopic 225
-Section S99
-Paragraph 1
-Subparagraph (SX 210.7-04(18))
-URI http://asc.fasb.org/extlink&oid=6879464&loc=d3e573970-122913

Reference 5: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
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Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.

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The net result for the period of deducting operating expenses from operating revenues.

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Aggregate revenue during the period from the sale of goods in the normal course of business, after deducting returns, allowances and discounts.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
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-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1(a))
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