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The Company (Details) $ in Thousands		1 Months Ended	3 Months Ended
	Apr. 20, 2017 USD ($) shares	Aug. 31, 2014 member_state	Mar. 31, 2018 USD ($) number_country	Dec. 31, 2017 USD ($)	Aug. 31, 2015
Long-term debt
Minimum age of ambulatory patient		5 years
Number of member states of the European Economic Area | member_state		31
Retained earnings (accumulated deficit)			$ (830,105)	$ (814,108)
Convertible debt | 3.00% Convertible senior notes due 2022
Long-term debt
Interest rate					3.00%
Non-collaborative Arrangement Transactions | Marathon Pharmaceuticals, LLC
Long-term debt
Cash consideration	$ 75,000
Equity Interest Issued, number of shares (in shares) | shares	6,683,598
Numerator for calculation of number of shares of equity interests issued to acquire entity	$ 65,000
Trading day period	15 days
Development and regulatory milestone payments which the entity may be obligated to pay	$ 50,000
Translarna
Long-term debt
Number of countries | number_country			25

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